FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007947633> ?p ?o ?g. }

• W2007947633 endingPage "986" @default.
• W2007947633 startingPage "981" @default.
• W2007947633 abstract "Many genes and signaling pathways are involved in renal cell carcinoma (RCC) development. However, genetic tumor markers have not gained use in RCC diagnostics and prognosis prediction. Identification and evaluation of new molecular parameters are of utmost importance in cancer research and cancer treatment. Here we present a novel approach to rapidly identify clinically relevant molecular changes in cancer. To identify genes with relevance to RCC, a cDNA array analysis was first performed on 5184 cDNA clones on a filter to screen for genes with differential expression between the renal cancer cell line CRL-1933 and normal kidney tissue. There were 89 differentially expressed genes in the cancer cell line, one of them coding for vimentin, a cytoplasmic intermediate filament. In a second step, a renal cancer tissue microarray containing 532 RCC specimen was used to determine vimentin expression by immunohistochemistry. Vimentin expression was seen frequently in clear cell (51%) and papillary RCC (61%), but rarely in chromophobe RCC (4%) and oncocytomas (12%). Furthermore, vimentin expression was significantly associated with poor patient prognosis (P < 0.007) independent of grade and stage. These results obtained from minute arrayed tumor samples match well with previous findings on vimentin expression in renal tumors. It is concluded that the combination of tumor arrays and cDNA arrays is a powerful approach to rapidly identify and further evaluate genes that play a role in tumor biology." @default.
• W2007947633 created "2016-06-24" @default.
• W2007947633 creator A5000570624 @default.
• W2007947633 creator A5007249612 @default.
• W2007947633 creator A5050670008 @default.
• W2007947633 creator A5053110552 @default.
• W2007947633 creator A5062191415 @default.
• W2007947633 creator A5062696264 @default.
• W2007947633 creator A5067223235 @default.
• W2007947633 creator A5076510325 @default.
• W2007947633 creator A5085335231 @default.
• W2007947633 date "1999-04-01" @default.
• W2007947633 modified "2023-09-27" @default.
• W2007947633 title "High-Throughput Tissue Microarray Analysis to Evaluate Genes Uncovered by cDNA Microarray Screening in Renal Cell Carcinoma" @default.
• W2007947633 cites W1592698345 @default.
• W2007947633 cites W181147267 @default.
• W2007947633 cites W1957709438 @default.
• W2007947633 cites W1980429073 @default.
• W2007947633 cites W1981823615 @default.
• W2007947633 cites W1986343884 @default.
• W2007947633 cites W1989031683 @default.
• W2007947633 cites W2002964194 @default.
• W2007947633 cites W2010160635 @default.
• W2007947633 cites W2026221868 @default.
• W2007947633 cites W2028400858 @default.
• W2007947633 cites W2048834398 @default.
• W2007947633 cites W2086578727 @default.
• W2007947633 cites W2087810003 @default.
• W2007947633 cites W2111441107 @default.
• W2007947633 cites W2112775523 @default.
• W2007947633 cites W2133590033 @default.
• W2007947633 cites W2137622686 @default.
• W2007947633 cites W2137895670 @default.
• W2007947633 cites W2333444352 @default.
• W2007947633 cites W238668910 @default.
• W2007947633 cites W2408232533 @default.
• W2007947633 cites W2414469329 @default.
• W2007947633 cites W4302969546 @default.
• W2007947633 cites W49229192 @default.
• W2007947633 cites W88995357 @default.
• W2007947633 doi "https://doi.org/10.1016/s0002-9440(10)65349-7" @default.
• W2007947633 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1866554" @default.
• W2007947633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10233835" @default.
• W2007947633 hasPublicationYear "1999" @default.
• W2007947633 type Work @default.
• W2007947633 sameAs 2007947633 @default.
• W2007947633 citedByCount "367" @default.
• W2007947633 countsByYear W20079476332012 @default.
• W2007947633 countsByYear W20079476332013 @default.
• W2007947633 countsByYear W20079476332014 @default.
• W2007947633 countsByYear W20079476332015 @default.
• W2007947633 countsByYear W20079476332016 @default.
• W2007947633 countsByYear W20079476332017 @default.
• W2007947633 countsByYear W20079476332018 @default.
• W2007947633 countsByYear W20079476332019 @default.
• W2007947633 countsByYear W20079476332020 @default.
• W2007947633 countsByYear W20079476332021 @default.
• W2007947633 countsByYear W20079476332022 @default.
• W2007947633 countsByYear W20079476332023 @default.
• W2007947633 crossrefType "journal-article" @default.
• W2007947633 hasAuthorship W2007947633A5000570624 @default.
• W2007947633 hasAuthorship W2007947633A5007249612 @default.
• W2007947633 hasAuthorship W2007947633A5050670008 @default.
• W2007947633 hasAuthorship W2007947633A5053110552 @default.
• W2007947633 hasAuthorship W2007947633A5062191415 @default.
• W2007947633 hasAuthorship W2007947633A5062696264 @default.
• W2007947633 hasAuthorship W2007947633A5067223235 @default.
• W2007947633 hasAuthorship W2007947633A5076510325 @default.
• W2007947633 hasAuthorship W2007947633A5085335231 @default.
• W2007947633 hasBestOaLocation W20079476331 @default.
• W2007947633 hasConcept C104317684 @default.
• W2007947633 hasConcept C121608353 @default.
• W2007947633 hasConcept C142724271 @default.
• W2007947633 hasConcept C147447768 @default.
• W2007947633 hasConcept C150194340 @default.
• W2007947633 hasConcept C153911025 @default.
• W2007947633 hasConcept C186836561 @default.
• W2007947633 hasConcept C187882448 @default.
• W2007947633 hasConcept C193270364 @default.
• W2007947633 hasConcept C203014093 @default.
• W2007947633 hasConcept C204232928 @default.
• W2007947633 hasConcept C2777472916 @default.
• W2007947633 hasConcept C2778560582 @default.
• W2007947633 hasConcept C2780674462 @default.
• W2007947633 hasConcept C2781068499 @default.
• W2007947633 hasConcept C502942594 @default.
• W2007947633 hasConcept C54355233 @default.
• W2007947633 hasConcept C71924100 @default.
• W2007947633 hasConcept C78795084 @default.
• W2007947633 hasConcept C8415881 @default.
• W2007947633 hasConcept C86803240 @default.
• W2007947633 hasConceptScore W2007947633C104317684 @default.
• W2007947633 hasConceptScore W2007947633C121608353 @default.
• W2007947633 hasConceptScore W2007947633C142724271 @default.
• W2007947633 hasConceptScore W2007947633C147447768 @default.
• W2007947633 hasConceptScore W2007947633C150194340 @default.
• W2007947633 hasConceptScore W2007947633C153911025 @default.
• W2007947633 hasConceptScore W2007947633C186836561 @default.

• next