Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007954658> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2007954658 endingPage "94" @default.
- W2007954658 startingPage "89" @default.
- W2007954658 abstract "Cytochrome P450(11β) is deeply involved in the final steps of biosynthesis of mineralocorticoids. This paper deals with following issues about this enzyme. (1) The structure and function of the enzymes of various animal species are discussed. By making alignment of amino acid sequences of the enzymes, we identified peptide domains essential for the enzyme actions such as a putative steroid binding domain and a heme binding region. Estimates of molecular similarity among the P450(11β) family enzymes suggested that the enzymes having both 11β-hydroxylation activity and aldosterone (ALDO) synthetic activity of certain animals such as frog, cattle and pig are more similar to the ALDO synthases of the other animals, such as rat, mouse and human, than the 11β-hydroxylases of these animals. (2) The molecular nature of the P450(11β) family enzymes of genetically hypertensive rats as well as adrenal regeneration hypertension (ARH) rats is examined. (i) Mutation was found in the P450(11β) gene of Dahl's salt-resistant normotensive rat. Steroidogenic activity expressed by the mutated gene accounted well for abnormal plasma levels of steroid hormones in this rat. (ii) 11β-, 18- and 19-Hydroxylation activities of adrenal mitochondria prepared from spontaneously hypertensive rat (SHR), Wistar-Kyoto rat (WKY), and stroke-prone (SP)-SHR were not significantly different from each other. Levels of mRNA of ALDO synthase in adrenal glands of 50-week-old SHR was significantly lower than those of 10-week-old SHR, WKY and SHR-SP. (iii) No significant difference in 19-hydroxylation activity was found between adrenal mitochondria prepared from ARH rat and those from control rat. The level of message of ALDO synthase was lower in adrenal glands of ARH rat." @default.
- W2007954658 created "2016-06-24" @default.
- W2007954658 creator A5024122921 @default.
- W2007954658 creator A5031128573 @default.
- W2007954658 creator A5032183957 @default.
- W2007954658 creator A5035657531 @default.
- W2007954658 creator A5036897372 @default.
- W2007954658 creator A5044706467 @default.
- W2007954658 creator A5075577872 @default.
- W2007954658 creator A5081531064 @default.
- W2007954658 creator A5082159773 @default.
- W2007954658 creator A5090188816 @default.
- W2007954658 date "1995-06-01" @default.
- W2007954658 modified "2023-09-27" @default.
- W2007954658 title "Cytochrome P450(11β): Structure-function relationship of the enzyme and its involvement in blood pressure regulation" @default.
- W2007954658 cites W1529137549 @default.
- W2007954658 cites W1889408717 @default.
- W2007954658 cites W1930503635 @default.
- W2007954658 cites W1989657305 @default.
- W2007954658 cites W1990953561 @default.
- W2007954658 cites W1995810012 @default.
- W2007954658 cites W2001395621 @default.
- W2007954658 cites W2033345598 @default.
- W2007954658 cites W2036079918 @default.
- W2007954658 cites W2051229276 @default.
- W2007954658 cites W2058006466 @default.
- W2007954658 cites W2069528760 @default.
- W2007954658 cites W2082078635 @default.
- W2007954658 cites W2130792052 @default.
- W2007954658 cites W2291114795 @default.
- W2007954658 cites W299769444 @default.
- W2007954658 cites W4296981502 @default.
- W2007954658 doi "https://doi.org/10.1016/0960-0760(95)00025-u" @default.
- W2007954658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7626522" @default.
- W2007954658 hasPublicationYear "1995" @default.
- W2007954658 type Work @default.
- W2007954658 sameAs 2007954658 @default.
- W2007954658 citedByCount "13" @default.
- W2007954658 countsByYear W20079546582015 @default.
- W2007954658 crossrefType "journal-article" @default.
- W2007954658 hasAuthorship W2007954658A5024122921 @default.
- W2007954658 hasAuthorship W2007954658A5031128573 @default.
- W2007954658 hasAuthorship W2007954658A5032183957 @default.
- W2007954658 hasAuthorship W2007954658A5035657531 @default.
- W2007954658 hasAuthorship W2007954658A5036897372 @default.
- W2007954658 hasAuthorship W2007954658A5044706467 @default.
- W2007954658 hasAuthorship W2007954658A5075577872 @default.
- W2007954658 hasAuthorship W2007954658A5081531064 @default.
- W2007954658 hasAuthorship W2007954658A5082159773 @default.
- W2007954658 hasAuthorship W2007954658A5090188816 @default.
- W2007954658 hasConcept C104317684 @default.
- W2007954658 hasConcept C126322002 @default.
- W2007954658 hasConcept C134018914 @default.
- W2007954658 hasConcept C181199279 @default.
- W2007954658 hasConcept C185592680 @default.
- W2007954658 hasConcept C2778525890 @default.
- W2007954658 hasConcept C2781109383 @default.
- W2007954658 hasConcept C526171541 @default.
- W2007954658 hasConcept C55493867 @default.
- W2007954658 hasConcept C71924100 @default.
- W2007954658 hasConcept C86803240 @default.
- W2007954658 hasConceptScore W2007954658C104317684 @default.
- W2007954658 hasConceptScore W2007954658C126322002 @default.
- W2007954658 hasConceptScore W2007954658C134018914 @default.
- W2007954658 hasConceptScore W2007954658C181199279 @default.
- W2007954658 hasConceptScore W2007954658C185592680 @default.
- W2007954658 hasConceptScore W2007954658C2778525890 @default.
- W2007954658 hasConceptScore W2007954658C2781109383 @default.
- W2007954658 hasConceptScore W2007954658C526171541 @default.
- W2007954658 hasConceptScore W2007954658C55493867 @default.
- W2007954658 hasConceptScore W2007954658C71924100 @default.
- W2007954658 hasConceptScore W2007954658C86803240 @default.
- W2007954658 hasIssue "1-6" @default.
- W2007954658 hasLocation W20079546581 @default.
- W2007954658 hasLocation W20079546582 @default.
- W2007954658 hasOpenAccess W2007954658 @default.
- W2007954658 hasPrimaryLocation W20079546581 @default.
- W2007954658 hasRelatedWork W164398201 @default.
- W2007954658 hasRelatedWork W1967659878 @default.
- W2007954658 hasRelatedWork W2005378862 @default.
- W2007954658 hasRelatedWork W2012531534 @default.
- W2007954658 hasRelatedWork W2017346924 @default.
- W2007954658 hasRelatedWork W2030344337 @default.
- W2007954658 hasRelatedWork W2032439565 @default.
- W2007954658 hasRelatedWork W2067328017 @default.
- W2007954658 hasRelatedWork W2096740894 @default.
- W2007954658 hasRelatedWork W4234160658 @default.
- W2007954658 hasVolume "53" @default.
- W2007954658 isParatext "false" @default.
- W2007954658 isRetracted "false" @default.
- W2007954658 magId "2007954658" @default.
- W2007954658 workType "article" @default.