FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007962104> ?p ?o ?g. }

• W2007962104 endingPage "913" @default.
• W2007962104 startingPage "908" @default.
• W2007962104 abstract "Protein deprivation in young rats retards growth and decreases serum insulin-like growth factor-I (IGF-I) concentrations, neither of which is prevented by injections of GH once daily. Since four time daily injections of GH in hypophysectomized rats increase serum IGF-I concentrations more efficiently than single daily injections, we assessed whether this mode of GH delivery could overcome the GH resistance of protein malnutrition. Also, we evaluated whether continuous GH infusion could override this GH resistance. We fed 4-week-old female Wistar rats a low (5%) protein diet (P5) or a normal (15%) protein diet (P15) for 7 days. In a first experiment, rats fed a P5 diet received 40 or 400 μg/100 g BWday rat GH (rGH) in four daily sc injections, while control P5 rats were injected at the same frequency with vehicle. In a second experiment, rats fed a P5 diet received 200 μg rGH/100 g BW-day by continuous infusion, while P5 sham-operated rats served as controls. IGF-I was measured by RIA on extracted serum, and free and total liver GH binding were determined by incubation of [125I] bovine GH with water- or MgCl2-treated homogenates, respectively. Neither continuous infusion nor repeated injections of rGH normalized the indices of growth or restored the serum IGF-I level to P15 control values. Injections of 400 ng rGH increased serum IGF-I 2-fold (P < 0.01), but did not promote growth. Continuous GH infusion increased total and free liver GH binding to P15 control values, but had no effect on serum IGFI. The discordance between liver GH binding and IGF-I confirms that a postreceptor defect is responsible for the GH resistance in protein restriction. These observations demonstrate that the consequences of protein restriction on growth are not overridden by intermittent or continuous administration of GH. The increase in IGF-I in response to 400 μg GH given intermittently in the absence of growth-promoting effects suggests that nutritional sufficiency is essential for IGF-I to promote growth. (Endocrinology126: 908–913,1990)" @default.
• W2007962104 created "2016-06-24" @default.
• W2007962104 creator A5018575728 @default.
• W2007962104 creator A5043646063 @default.
• W2007962104 creator A5061345613 @default.
• W2007962104 creator A5071155108 @default.
• W2007962104 creator A5091888132 @default.
• W2007962104 date "1990-02-01" @default.
• W2007962104 modified "2023-10-15" @default.
• W2007962104 title "Divergent Responses of Serum Insulin-Like Growth Factor-I and Liver Growth Hormone (GH) Receptors to Exogenous GH in Protein-Restricted Rats*" @default.
• W2007962104 cites W1541768292 @default.
• W2007962104 cites W1775749144 @default.
• W2007962104 cites W1963652511 @default.
• W2007962104 cites W1970286905 @default.
• W2007962104 cites W1985245731 @default.
• W2007962104 cites W1989877527 @default.
• W2007962104 cites W1998169782 @default.
• W2007962104 cites W2002721328 @default.
• W2007962104 cites W2007298026 @default.
• W2007962104 cites W2025381000 @default.
• W2007962104 cites W2028753279 @default.
• W2007962104 cites W2029425460 @default.
• W2007962104 cites W2032213598 @default.
• W2007962104 cites W2034556883 @default.
• W2007962104 cites W2037724297 @default.
• W2007962104 cites W2066724606 @default.
• W2007962104 cites W2078855887 @default.
• W2007962104 cites W2093332217 @default.
• W2007962104 cites W2134054616 @default.
• W2007962104 cites W2141829815 @default.
• W2007962104 cites W44893099 @default.
• W2007962104 doi "https://doi.org/10.1210/endo-126-2-908" @default.
• W2007962104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2298175" @default.
• W2007962104 hasPublicationYear "1990" @default.
• W2007962104 type Work @default.
• W2007962104 sameAs 2007962104 @default.
• W2007962104 citedByCount "63" @default.
• W2007962104 countsByYear W20079621042013 @default.
• W2007962104 countsByYear W20079621042015 @default.
• W2007962104 countsByYear W20079621042016 @default.
• W2007962104 countsByYear W20079621042018 @default.
• W2007962104 countsByYear W20079621042022 @default.
• W2007962104 crossrefType "journal-article" @default.
• W2007962104 hasAuthorship W2007962104A5018575728 @default.
• W2007962104 hasAuthorship W2007962104A5043646063 @default.
• W2007962104 hasAuthorship W2007962104A5061345613 @default.
• W2007962104 hasAuthorship W2007962104A5071155108 @default.
• W2007962104 hasAuthorship W2007962104A5091888132 @default.
• W2007962104 hasBestOaLocation W20079621041 @default.
• W2007962104 hasConcept C113675107 @default.
• W2007962104 hasConcept C126322002 @default.
• W2007962104 hasConcept C134018914 @default.
• W2007962104 hasConcept C170493617 @default.
• W2007962104 hasConcept C2775960820 @default.
• W2007962104 hasConcept C2778328710 @default.
• W2007962104 hasConcept C2780378035 @default.
• W2007962104 hasConcept C2780689927 @default.
• W2007962104 hasConcept C2910954651 @default.
• W2007962104 hasConcept C2984496839 @default.
• W2007962104 hasConcept C71315377 @default.
• W2007962104 hasConcept C71924100 @default.
• W2007962104 hasConcept C80862487 @default.
• W2007962104 hasConcept C86803240 @default.
• W2007962104 hasConceptScore W2007962104C113675107 @default.
• W2007962104 hasConceptScore W2007962104C126322002 @default.
• W2007962104 hasConceptScore W2007962104C134018914 @default.
• W2007962104 hasConceptScore W2007962104C170493617 @default.
• W2007962104 hasConceptScore W2007962104C2775960820 @default.
• W2007962104 hasConceptScore W2007962104C2778328710 @default.
• W2007962104 hasConceptScore W2007962104C2780378035 @default.
• W2007962104 hasConceptScore W2007962104C2780689927 @default.
• W2007962104 hasConceptScore W2007962104C2910954651 @default.
• W2007962104 hasConceptScore W2007962104C2984496839 @default.
• W2007962104 hasConceptScore W2007962104C71315377 @default.
• W2007962104 hasConceptScore W2007962104C71924100 @default.
• W2007962104 hasConceptScore W2007962104C80862487 @default.
• W2007962104 hasConceptScore W2007962104C86803240 @default.
• W2007962104 hasIssue "2" @default.
• W2007962104 hasLocation W20079621041 @default.
• W2007962104 hasLocation W20079621042 @default.
• W2007962104 hasOpenAccess W2007962104 @default.
• W2007962104 hasPrimaryLocation W20079621041 @default.
• W2007962104 hasRelatedWork W152612465 @default.
• W2007962104 hasRelatedWork W2006827179 @default.
• W2007962104 hasRelatedWork W2009007240 @default.
• W2007962104 hasRelatedWork W2016473857 @default.
• W2007962104 hasRelatedWork W2018976360 @default.
• W2007962104 hasRelatedWork W2062931494 @default.
• W2007962104 hasRelatedWork W2102913489 @default.
• W2007962104 hasRelatedWork W2146349404 @default.
• W2007962104 hasRelatedWork W2166837082 @default.
• W2007962104 hasRelatedWork W66663417 @default.
• W2007962104 hasVolume "126" @default.
• W2007962104 isParatext "false" @default.
• W2007962104 isRetracted "false" @default.
• W2007962104 magId "2007962104" @default.
• W2007962104 workType "article" @default.