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• W2007962912 abstract "Vulval induction during Caenorhabditis elegans development is mediated by LET-23, a homolog of the mammalian epidermal growth factor receptor tyrosine kinase. The sli-1 gene is a negative regulator of LET-23 and is shown here to encode a protein similar to c-Cbl, a mammalian proto-oncoprotein. SLI-1 and c-Cbl share approximately 55 percent amino acid identity over a stretch of 390 residues, which includes a C3HC4 zinc-binding motif known as the RING finger, and multiple consensus binding sites for Src homology 3 (SH3) domains. SLI-1 and c-Cbl may define a new class of proteins that modify receptor tyrosine kinase-mediated signal transduction." @default.
• W2007962912 created "2016-06-24" @default.
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• W2007962912 date "1995-08-25" @default.
• W2007962912 modified "2023-10-18" @default.
• W2007962912 title "Similarity of <i>sli-1</i> , a Regulator of Vulval Development in <i>C. elegans</i> , to the Mammalian Proto-Oncogene c- <i>cbl</i>" @default.
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• W2007962912 doi "https://doi.org/10.1126/science.7652556" @default.
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