FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007965470> ?p ?o ?g. }

• W2007965470 endingPage "420" @default.
• W2007965470 startingPage "419" @default.
• W2007965470 abstract "ArticlePlus Click on the links below to access all the ArticlePlus for this article. Please note that ArticlePlus files may launch a viewer application outside of your web browser. https://links.lww.com/EDE/A157 https://links.lww.com/EDE/A158 To the Editor: Placental abruption (premature placental separation from the uterus) and placental infarction (often resulting from microscopic thrombi or clots within placental blood vessels) are associated with increased risks of stillbirth,1 intrauterine growth restriction,1,2 and preterm delivery.1–3 Folate deficiency has been suggested to be associated with placental abruption and infarction (pooled odds ratio = 26; 95% confidence interval = 0.9–736).4 Canadian white flour has been fortified with folic acid since January 1998. We performed an analysis to determine if there was a change in the rate of placental abruption and infarction in relation to folic acid food fortification. We conducted a retrospective population-based study of the monthly prevalence of placental abruption and infarction (calculated by dividing the number of women hospitalized with a diagnosis of either condition in a given month by all women who gave birth to a live-born or stillborn infant >20 weeks’ gestation age within the same month). The exposure of interest was the mandatory folic acid food fortification, with the prefortification period was defined as January 1, 1995, to September 30, 1998 (allowing a lag effect of 9 months for gestation) and postfortification from October 1, 1998, to March 31, 2001. Pregnancies affected by placental abruption or placental infarction were identified using the Canadian Institute for Health Information Discharge Abstract Database, which contains up to 16 diagnoses, coded by International Classification of Diseases, 9th Revision. Codes used are listed in Appendix 1 (available with the electronic version of this letter). Complete data for the province of Quebec and the Northwest Territories, Yukon and Nunavut, were not available and were excluded. A crude prevalence ratio (PR) compared the prevalence of placental abruption in the periods before and during fortification. Poisson regression was used to adjust the PR for maternal age >35 years, as well as the covariates listed in electronic Appendix 1. These analyses were repeated for placental abruption or placental infarction. All patient identifiers were removed before database extraction. Permission to conduct this study was granted by the Research Ethics Board of Mount Sinai Hospital, Toronto. There were 1,159,329 deliveries before fortification and 695,154 in the period thereafter. Participant characteristics are presented in electronic Appendix 2. Monthly prevalences of placental pathologic events are shown in electronic Appendix 3. No change in association with fortification was observed in the risk of placental abruption in either univariate (1.02; 0.99–1.05) or multivariate analyses (1.02; 0.98–1.05) (Table 1). Similar risk estimates were observed for placental abruption or placental infarction separately.TABLE 1: Risk of Placental Abruption or Infarction in Association With Folic Acid Food FortificationWe had no information on maternal weight or cigarette smoking (risk factors for placental disease), folic acid supplement use, or serum folate concentrations. However, since fortification began, red cell folate concentrations have increased by more than 40% among Canadian women,5 and the relative prevalence of folate deficiency declined by more than 85%.6 Our study included nearly all Canadian women who delivered over a 6-year period, with nearly 100% statistical power to detect as little as a 1% change in the prevalence of placental abruption. Thus, it is unlikely that folic acid can prevent abruption or infarction. ACKNOWLEDGMENTS Supported by the physicians of Ontario through the Physicians’ Services Incorporated Foundation, Sunnybrooke and Women's College Foundation, and John Kingdom. Sarah D. McDonald Clinical Epidemiology Unit Ottawa Hospital Ottawa, Ontario, Canada [email protected] Marian J. Vermeulen Institute for Clinical Evaluative Sciences Toronto, Ontario, Canada Joel G. Ray St. Michael's Hospital, University of Toronto Toronto, Ontario, Canada" @default.
• W2007965470 created "2016-06-24" @default.
• W2007965470 creator A5001067933 @default.
• W2007965470 creator A5024987673 @default.
• W2007965470 creator A5067352224 @default.
• W2007965470 date "2005-05-01" @default.
• W2007965470 modified "2023-10-18" @default.
• W2007965470 title "Folic Acid and Placental Pathology" @default.
• W2007965470 cites W1556263173 @default.
• W2007965470 cites W2090474126 @default.
• W2007965470 cites W2124588032 @default.
• W2007965470 cites W2169259236 @default.
• W2007965470 cites W2325574448 @default.
• W2007965470 doi "https://doi.org/10.1097/01.ede.0000158796.65387.68" @default.
• W2007965470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15824569" @default.
• W2007965470 hasPublicationYear "2005" @default.
• W2007965470 type Work @default.
• W2007965470 sameAs 2007965470 @default.
• W2007965470 citedByCount "6" @default.
• W2007965470 countsByYear W20079654702012 @default.
• W2007965470 crossrefType "journal-article" @default.
• W2007965470 hasAuthorship W2007965470A5001067933 @default.
• W2007965470 hasAuthorship W2007965470A5024987673 @default.
• W2007965470 hasAuthorship W2007965470A5067352224 @default.
• W2007965470 hasBestOaLocation W20079654701 @default.
• W2007965470 hasConcept C126322002 @default.
• W2007965470 hasConcept C131872663 @default.
• W2007965470 hasConcept C156957248 @default.
• W2007965470 hasConcept C2779225303 @default.
• W2007965470 hasConcept C2779234561 @default.
• W2007965470 hasConcept C2908647359 @default.
• W2007965470 hasConcept C29456083 @default.
• W2007965470 hasConcept C46973012 @default.
• W2007965470 hasConcept C54355233 @default.
• W2007965470 hasConcept C71924100 @default.
• W2007965470 hasConcept C86803240 @default.
• W2007965470 hasConcept C99454951 @default.
• W2007965470 hasConceptScore W2007965470C126322002 @default.
• W2007965470 hasConceptScore W2007965470C131872663 @default.
• W2007965470 hasConceptScore W2007965470C156957248 @default.
• W2007965470 hasConceptScore W2007965470C2779225303 @default.
• W2007965470 hasConceptScore W2007965470C2779234561 @default.
• W2007965470 hasConceptScore W2007965470C2908647359 @default.
• W2007965470 hasConceptScore W2007965470C29456083 @default.
• W2007965470 hasConceptScore W2007965470C46973012 @default.
• W2007965470 hasConceptScore W2007965470C54355233 @default.
• W2007965470 hasConceptScore W2007965470C71924100 @default.
• W2007965470 hasConceptScore W2007965470C86803240 @default.
• W2007965470 hasConceptScore W2007965470C99454951 @default.
• W2007965470 hasIssue "3" @default.
• W2007965470 hasLocation W20079654701 @default.
• W2007965470 hasLocation W20079654702 @default.
• W2007965470 hasOpenAccess W2007965470 @default.
• W2007965470 hasPrimaryLocation W20079654701 @default.
• W2007965470 hasRelatedWork W2045750308 @default.
• W2007965470 hasRelatedWork W2055556486 @default.
• W2007965470 hasRelatedWork W2132209241 @default.
• W2007965470 hasRelatedWork W2801372868 @default.
• W2007965470 hasRelatedWork W2984517669 @default.
• W2007965470 hasRelatedWork W3003904031 @default.
• W2007965470 hasRelatedWork W3114536737 @default.
• W2007965470 hasRelatedWork W3163987424 @default.
• W2007965470 hasRelatedWork W4281694272 @default.
• W2007965470 hasRelatedWork W985205842 @default.
• W2007965470 hasVolume "16" @default.
• W2007965470 isParatext "false" @default.
• W2007965470 isRetracted "false" @default.
• W2007965470 magId "2007965470" @default.
• W2007965470 workType "article" @default.