FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007971966> ?p ?o ?g. }

• W2007971966 endingPage "1517" @default.
• W2007971966 startingPage "1507" @default.
• W2007971966 abstract "1. The antimuscarinic effects of tripitramine were investigated in vitro in isolated driven left (force) and spontaneously beating right (force and rate) atria as well as in the ileum of guinea-pig and rat and in the trachea and lung strip of guinea-pig and compared with the effects of methoctramine. 2. Tripitramine was a potent competitive antagonist of muscarinic M2 receptors in right and left atria. The pA2 values ranged from 9.14 to 9.85. However, in the guinea-pig and rat left atria but not in guinea-pig right atria, tripitramine at lower concentrations (3-10 nM) produced a less than proportional displacement to the right of agonist-induced responses owing to the presence of a possible saturable removal process. 3. Tripitramine was about three orders of magnitude less potent in ileal and tracheal than in atrial preparations (pA2 values ranging from 6.34 to 6.81) which makes it more potent and more selective than methoctramine. 4. Another intriguing finding was the observation that the pA2 value of 7.91 observed for tripitramine in guinea-pig lung does not correlate with that found at both muscarinic M2 and M3 receptor subtypes, which clearly indicates that the contraction of guinea-pig lung strip is not mediated by these muscarinic receptor subtypes. 5. A combination of tripitramine with atropine resulted in addition of the dose-ratios for left atria as required for two antagonists interacting competitively with the same receptor site, whereas the same combination gave a supra-additive antagonism on guinea-pig ileum which suggests that tripitramine interacts with a second interdependent site. 6. Tripitramine was more specific than methoctramine since, in addition to muscarinic receptors, it inhibited only frog rectus abdominis muscular (pIC50 value of 6.14) and rat duodenum neuronal (pIC50 value of 4.87) nicotinic receptors among receptor systems investigated, namely alpha 1-, alpha 2-, and beta 1-adrenoceptors, H1- and H2-histamine receptors, and muscular and neuronal nicotinic receptors." @default.
• W2007971966 created "2016-06-24" @default.
• W2007971966 creator A5023513144 @default.
• W2007971966 creator A5047663206 @default.
• W2007971966 creator A5069833831 @default.
• W2007971966 creator A5082587338 @default.
• W2007971966 creator A5084691569 @default.
• W2007971966 date "1995-04-01" @default.
• W2007971966 modified "2023-10-12" @default.
• W2007971966 title "In vitro characterization of tripitramine, a polymethylene tetraamine displaying high selectivity and affinity for muscarinic M2 receptors" @default.
• W2007971966 cites W1650621942 @default.
• W2007971966 cites W1753462683 @default.
• W2007971966 cites W1872200504 @default.
• W2007971966 cites W1953072265 @default.
• W2007971966 cites W1968646027 @default.
• W2007971966 cites W1972244086 @default.
• W2007971966 cites W1972548492 @default.
• W2007971966 cites W1974018894 @default.
• W2007971966 cites W1974367753 @default.
• W2007971966 cites W1975419461 @default.
• W2007971966 cites W1975789340 @default.
• W2007971966 cites W1989208794 @default.
• W2007971966 cites W1991506551 @default.
• W2007971966 cites W1999600294 @default.
• W2007971966 cites W2003020279 @default.
• W2007971966 cites W2007688885 @default.
• W2007971966 cites W2018909032 @default.
• W2007971966 cites W2025482742 @default.
• W2007971966 cites W2028413677 @default.
• W2007971966 cites W2033184198 @default.
• W2007971966 cites W2033970938 @default.
• W2007971966 cites W2034433098 @default.
• W2007971966 cites W2041005648 @default.
• W2007971966 cites W2042403615 @default.
• W2007971966 cites W2052821851 @default.
• W2007971966 cites W2055990896 @default.
• W2007971966 cites W2057971042 @default.
• W2007971966 cites W2058977200 @default.
• W2007971966 cites W2071820905 @default.
• W2007971966 cites W2072317447 @default.
• W2007971966 cites W2078331771 @default.
• W2007971966 cites W2080335457 @default.
• W2007971966 cites W2087158652 @default.
• W2007971966 cites W2104395061 @default.
• W2007971966 cites W2113630547 @default.
• W2007971966 cites W2116955311 @default.
• W2007971966 cites W2128382686 @default.
• W2007971966 cites W2163381401 @default.
• W2007971966 cites W2397485333 @default.
• W2007971966 cites W2416243545 @default.
• W2007971966 cites W2417852834 @default.
• W2007971966 cites W44420309 @default.
• W2007971966 doi "https://doi.org/10.1111/j.1476-5381.1995.tb13378.x" @default.
• W2007971966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1510296" @default.
• W2007971966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7606355" @default.
• W2007971966 hasPublicationYear "1995" @default.
• W2007971966 type Work @default.
• W2007971966 sameAs 2007971966 @default.
• W2007971966 citedByCount "30" @default.
• W2007971966 countsByYear W20079719662012 @default.
• W2007971966 countsByYear W20079719662014 @default.
• W2007971966 countsByYear W20079719662015 @default.
• W2007971966 countsByYear W20079719662020 @default.
• W2007971966 crossrefType "journal-article" @default.
• W2007971966 hasAuthorship W2007971966A5023513144 @default.
• W2007971966 hasAuthorship W2007971966A5047663206 @default.
• W2007971966 hasAuthorship W2007971966A5069833831 @default.
• W2007971966 hasAuthorship W2007971966A5082587338 @default.
• W2007971966 hasAuthorship W2007971966A5084691569 @default.
• W2007971966 hasBestOaLocation W20079719661 @default.
• W2007971966 hasConcept C116289061 @default.
• W2007971966 hasConcept C126322002 @default.
• W2007971966 hasConcept C134018914 @default.
• W2007971966 hasConcept C163415756 @default.
• W2007971966 hasConcept C170493617 @default.
• W2007971966 hasConcept C185592680 @default.
• W2007971966 hasConcept C2775859210 @default.
• W2007971966 hasConcept C2776961477 @default.
• W2007971966 hasConcept C2777226302 @default.
• W2007971966 hasConcept C2778815084 @default.
• W2007971966 hasConcept C2778938600 @default.
• W2007971966 hasConcept C33789571 @default.
• W2007971966 hasConcept C47488739 @default.
• W2007971966 hasConcept C71924100 @default.
• W2007971966 hasConcept C86803240 @default.
• W2007971966 hasConceptScore W2007971966C116289061 @default.
• W2007971966 hasConceptScore W2007971966C126322002 @default.
• W2007971966 hasConceptScore W2007971966C134018914 @default.
• W2007971966 hasConceptScore W2007971966C163415756 @default.
• W2007971966 hasConceptScore W2007971966C170493617 @default.
• W2007971966 hasConceptScore W2007971966C185592680 @default.
• W2007971966 hasConceptScore W2007971966C2775859210 @default.
• W2007971966 hasConceptScore W2007971966C2776961477 @default.
• W2007971966 hasConceptScore W2007971966C2777226302 @default.
• W2007971966 hasConceptScore W2007971966C2778815084 @default.
• W2007971966 hasConceptScore W2007971966C2778938600 @default.
• W2007971966 hasConceptScore W2007971966C33789571 @default.
• W2007971966 hasConceptScore W2007971966C47488739 @default.

• next