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- W2007973460 endingPage "9716" @default.
- W2007973460 startingPage "9716" @default.
- W2007973460 abstract "Colorectal cancer is a major cause of cancer-related death in many countries. Colorectal carcinogenesis is a stepwise process which, from normal mucosa leads to malignancy. Many factors have been shown to influence this process, however, at present, several points remain obscure. In recent years some hypotheses have been considered on the mechanisms involved in cancer development, expecially in its early stages. Tissue injury resulting from infectious, mechanical, or chemical agents may elicit a chronic immune response resulting in cellular proliferation and regeneration. Chronic inflammation of the large bowel (as in inflammatory bowel diseases), has been associated with the subsequent development of colorectal cancer. In this review we examine the inflammatory pathways involved in the early steps of carcinogenesis, with particular emphasis on colorectal. Firstly, we describe cells and proteins recently suggested as central in the mechanism leading to tumor development. Macrophages and neutrophils are among the cells mostly involved in these processes and proteins, as cyclooxygenases and resolvins, are crucial in these inflammatory pathways. Indeed, the activation of these pathways establishes an oxidative and anaerobic microenvironment with DNA damage to epithelial cells, and shifting from an aerobic to an anaerobic metabolism. Many cellular mechanisms, such as proliferation, apoptosis, and autophagy are altered causing failure to control normal mucosa repair and renewal." @default.
- W2007973460 created "2016-06-24" @default.
- W2007973460 creator A5024880642 @default.
- W2007973460 date "2014-01-01" @default.
- W2007973460 modified "2023-09-23" @default.
- W2007973460 title "Inflammatory pathways in the early steps of colorectal cancer development" @default.
- W2007973460 cites W1495797675 @default.
- W2007973460 cites W1503667331 @default.
- W2007973460 cites W1592051611 @default.
- W2007973460 cites W1649938880 @default.
- W2007973460 cites W1964190328 @default.
- W2007973460 cites W1966594595 @default.
- W2007973460 cites W1968442371 @default.
- W2007973460 cites W1971907885 @default.
- W2007973460 cites W1972944556 @default.
- W2007973460 cites W1979031126 @default.
- W2007973460 cites W1979166122 @default.
- W2007973460 cites W1985106074 @default.
- W2007973460 cites W1985859986 @default.
- W2007973460 cites W1988491976 @default.
- W2007973460 cites W1990547924 @default.
- W2007973460 cites W1992779495 @default.
- W2007973460 cites W1993353815 @default.
- W2007973460 cites W1994271130 @default.
- W2007973460 cites W1994523739 @default.
- W2007973460 cites W1997830990 @default.
- W2007973460 cites W1998533677 @default.
- W2007973460 cites W2000073606 @default.
- W2007973460 cites W2001717792 @default.
- W2007973460 cites W2003867270 @default.
- W2007973460 cites W2004684605 @default.
- W2007973460 cites W2005789183 @default.
- W2007973460 cites W2007187686 @default.
- W2007973460 cites W2007425253 @default.
- W2007973460 cites W2008854828 @default.
- W2007973460 cites W2011670785 @default.
- W2007973460 cites W2012908693 @default.
- W2007973460 cites W2014245338 @default.
- W2007973460 cites W2017347652 @default.
- W2007973460 cites W2019369653 @default.
- W2007973460 cites W2020068349 @default.
- W2007973460 cites W2021370278 @default.
- W2007973460 cites W2021632992 @default.
- W2007973460 cites W2027072794 @default.
- W2007973460 cites W2028274346 @default.
- W2007973460 cites W2028543411 @default.
- W2007973460 cites W2029857102 @default.
- W2007973460 cites W2031096140 @default.
- W2007973460 cites W2031346959 @default.
- W2007973460 cites W2031466731 @default.
- W2007973460 cites W2032639324 @default.
- W2007973460 cites W2032931851 @default.
- W2007973460 cites W2034896461 @default.
- W2007973460 cites W2038689279 @default.
- W2007973460 cites W2040252933 @default.
- W2007973460 cites W2041260419 @default.
- W2007973460 cites W2041318391 @default.
- W2007973460 cites W2044784487 @default.
- W2007973460 cites W2046056065 @default.
- W2007973460 cites W2047911550 @default.
- W2007973460 cites W2048727571 @default.
- W2007973460 cites W2051696368 @default.
- W2007973460 cites W2054472394 @default.
- W2007973460 cites W2054987125 @default.
- W2007973460 cites W2055912677 @default.
- W2007973460 cites W2057064377 @default.
- W2007973460 cites W2057854025 @default.
- W2007973460 cites W2059149560 @default.
- W2007973460 cites W2059364985 @default.
- W2007973460 cites W2062809449 @default.
- W2007973460 cites W2064424247 @default.
- W2007973460 cites W2065076024 @default.
- W2007973460 cites W2069968649 @default.
- W2007973460 cites W2071014725 @default.
- W2007973460 cites W2071143412 @default.
- W2007973460 cites W2071747218 @default.
- W2007973460 cites W2074171762 @default.
- W2007973460 cites W2083784822 @default.
- W2007973460 cites W2084708023 @default.
- W2007973460 cites W2086152184 @default.
- W2007973460 cites W2087765358 @default.
- W2007973460 cites W2090368420 @default.
- W2007973460 cites W2091327138 @default.
- W2007973460 cites W2091493364 @default.
- W2007973460 cites W2092769210 @default.
- W2007973460 cites W2093705034 @default.
- W2007973460 cites W2094156327 @default.
- W2007973460 cites W2094948210 @default.
- W2007973460 cites W2095744341 @default.
- W2007973460 cites W2096308078 @default.
- W2007973460 cites W2102354517 @default.
- W2007973460 cites W2103513948 @default.
- W2007973460 cites W2104479723 @default.
- W2007973460 cites W2105318331 @default.
- W2007973460 cites W2107028932 @default.
- W2007973460 cites W2108623724 @default.
- W2007973460 cites W2108717393 @default.
- W2007973460 cites W2109339035 @default.