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• W2007974307 abstract "We are not the genome generation. I recently attended a clinical diagnostics meeting where a speaker asked the audience (most of whom were at least middle aged) who would have their genome sequenced if it would be offered for free. Only a few hands were raised. In the discussion that followed, those that raised their hand were accused of being naive. Things do not appear to be much different in the wider public. People I talk to at birthday parties or on the school playground invariably have only the crudest understanding of genetics, genomics, and DNA. These people, and scientists who interact with them, would do well to read Elizabeth Finkel's latest book, entitled “The Genome Generation.” The book starts rather unimaginatively with the obligatory story of the discovery of DNA. However, in the next chapters, Finkel shakes off the dust and launches into discussions of 21st century genomics. Junk DNA is no longer junk. Lamarckism is back in the form of epigenetics. It is exciting stuff, which leaves the reader with no doubt that more discoveries are around the corner. These chapters make good reading for biologists who still adhere to the DNA-makes-RNA-makes-protein idea. Take notice because these are topics we need to know about. As Finkel puts it: “the age of dogmas is over.” In chapter 4, we finally arrive where the title of the book promised to take us. We are fast approaching the moment where each of us can have his or her genome sequenced for only a small amount of money. Instead of a health check, we might get a genomic Strengths, Weaknesses, Opportunities and Threats (SWOT) analysis. However, before we all carry around our genome on our laptop or mobile phone, we need to answer some questions. What do we want to know from our genome and what don't we want to know? More importantly, what can we know? The answer, at present, is rather disappointing. Despite much enthusiastic “gene mining,” we still do not understand the genetic architecture of most complex traits. Genome-wide association studies have left many hereditary diseases unexplained and therefore the personalized genomics company 23andMe cannot provide much health-related predictive information that is actually of use. Of course, these analyses are based on SNP chips that only cover a tiny fraction of our genome. Perhaps, whole-genome sequencing will open many new doors. But perhaps it won't. There is a real sense, conveyed well in the book, that we do not know where our genome information is going to take us. But not to worry. In subsequent chapters, we learn that the genome generation will be able to overcome AIDS and other diseases. This will result in many extra mouths, which the genome generation will be able to feed through a second, DNA-based green revolution. More convincingly, the genome generation will have a radically different understanding of how life works and why it works the way it does. They will understand much more deeply where we came from. Who is the genome generation? At another recent meeting on next-generation sequencing, one of the speakers asked the audience whether they would have their genome sequenced if it were done at no cost. More than two-thirds of hands were raised. The audience at this meeting? Mostly students. Naive, no doubt, but eager to explore this brave new world and ready to deal with the consequences. Things do not appear much different in the younger public. When my 7-year-old daughter spotted me wearing a fleece coat offered by a genomics company, she exclaimed: “Hey, daddy's got a DNA on his sweater!” We are not the genome generation; but the next generation most definitely will be." @default.
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• W2007974307 date "2012-07-11" @default.
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• W2007974307 title "The Genome Generation by Elizabeth Finkel" @default.
• W2007974307 doi "https://doi.org/10.1002/humu.22140" @default.
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