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• W2007988520 abstract "Developmental lead (Pb) exposure is associated with cognitive impairments in humans and rodents alike. In particular, impaired spatial learning and memory, as assessed using the Morris water maze (MWM), has been noted in developmentally Pb-exposed rats. Although sex and rearing environment can influence MWM performance in normal animals, the interactions of sex and rearing environment on the impact of developmental Pb exposure on hippocampal-dependent processes has not been well characterized. The present study examined the effects of perinatal exposure (i.e., gestation through weaning) to different levels of Pb (250, 750 and 1500 ppm Pb acetate in food) in males and females raised in a non-enriched environment (standard cage with 3 animals and no toys) or an enriched environment (large cage containing a variety of toys that were changed twice weekly). Testing in the MWM began at postnatal day 55. Behavioral outcomes were influenced by sex and rearing environment, with complex interactions with Pb exposure. In non-Pb exposed control animals, beneficial effects of environmental enrichment on spatial learning and memory were observed in males and females, with greater effects in females. Pb exposure in females mitigated at least some of the benefits of enrichment on learning, particularly at the lowest and highest exposure levels. In males, enrichment conferred a modest learning advantage and for the most part, Pb exposure did not affect this. However, in males with the highest Pb exposure, enrichment did help to overcome detrimental effects of Pb on learning. In females, any potential benefit to reference memory contributed by enrichment was muted by exposure to Pb and for the most part, this was not reproduced in males. Thus, there are complex interactions between sex, environment, and Pb exposure on spatial learning and memory. Environmental manipulation is a potential risk modifier of developmental Pb exposure and interacts with other factors including sex and amount of Pb exposure to affect the functional influences of Pb on the brain." @default.
• W2007988520 created "2016-06-24" @default.
• W2007988520 creator A5058796481 @default.
• W2007988520 creator A5084458781 @default.
• W2007988520 creator A5085765161 @default.
• W2007988520 date "2012-10-01" @default.
• W2007988520 modified "2023-10-16" @default.
• W2007988520 title "Sex and rearing condition modify the effects of perinatal lead exposure on learning and memory" @default.
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• W2007988520 doi "https://doi.org/10.1016/j.neuro.2012.04.016" @default.
• W2007988520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3430807" @default.
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• W2007988520 hasPublicationYear "2012" @default.
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