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- W2007992019 abstract "In vivo microdialysis in the frontal cortex of the freely moving guinea-pig was used to measure extracellular 5-hydroxytryptamine (5-HT) and study terminal autoreceptor control of its release. The indoleamine levels were determined by HPLC with electrochemical detection. Release of extracellular 5-HT and, to a lesser extent, 5-hydroxyindoleacetic acid was sensitive to tetrodotoxin, confirming the neuronal origin of measured neurotransmitter levels. Both systemic and local administration of the 5-HT1 agonist 5-carboxamidotryptamine caused inhibition of extracellular 5-HT levels, confirming the regulatory role of the terminal, and possibly also the somatodendritic, 5-HT autoreceptor on neuronal 5-HT release. Levels of extracellular 5-hydroxyindoleacetic acid were not affected by 5-carboxamidotryptamine following either central or peripheral administration." @default.
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- W2007992019 date "1992-01-01" @default.
- W2007992019 modified "2023-09-24" @default.
- W2007992019 title "Terminal Autoreceptor Control of 5-Hydroxytryptamine Release as Measured by In Vivo Microdialysis in the Conscious Guinea-Pig" @default.
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- W2007992019 doi "https://doi.org/10.1111/j.1471-4159.1992.tb09289.x" @default.
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