FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007992968> ?p ?o ?g. }

• W2007992968 endingPage "62" @default.
• W2007992968 startingPage "57" @default.
• W2007992968 abstract "1 A constant intraluminal pressure system was used to evaluate the effects of Kv1 channel blockers on the peristaltic activity of guinea-pig ileum. 2 The nortriterpene correolide, a non-selective inhibitor of all Kv1 sub-types, causes progressive and sustained reduction of the pressure threshold for eliciting peristaltic contractions. 3 Margatoxin (MgTX), alpha-dendrotoxin (alpha-DTX) and dendrotoxin-K (DTX-K), highly selective peptidyl inhibitors of certain Kv1 sub-types, cause immediate reduction of the pressure threshold. This effect subsides with time, irrespective of the peptides' concentration in the bath. In preparations pretreated with saturating concentrations of MgTX, correolide further stimulates the peristaltic activity. 4 Iberiotoxin (IbTX), a selective inhibitor of the high-conductance Ca(2+)-activated K(+) (BK) channels, and charybdotoxin (ChTX), which inhibits Kv1.2 and Kv1.3 as well as BK channels, fail to stimulate the peristaltic activity. 5 Blockade of muscarinic receptors by atropine reduces, and occasionally suppresses the peristaltic activity of guinea-pig ileum. In atropine-treated preparations, correolide and MgTX retain their abilities to reduce the pressure threshold and are able to restore the peristaltic reflex in the preparations where this reflex was suppressed by atropine. 6 The stimulatory effect of correolide and MgTX in atropine-treated preparations is abolished by subsequent addition of selective antagonists of both NK1 and NK2 receptors. 7 In conclusion, blockade of Kv1, particularly Kv1.1 channels, increases the peristaltic activity of guinea-pig ileum by enhancing the release of neurotransmitters at the enteric nervous system. In contrast, stimulation of the myogenic motility by blockade of BK channels does not affect the threshold for the peristaltic reflex." @default.
• W2007992968 created "2016-06-24" @default.
• W2007992968 creator A5007963409 @default.
• W2007992968 creator A5026860985 @default.
• W2007992968 creator A5042514932 @default.
• W2007992968 creator A5074411363 @default.
• W2007992968 creator A5077113337 @default.
• W2007992968 date "2003-01-01" @default.
• W2007992968 modified "2023-10-18" @default.
• W2007992968 title "Shaker-type Kv1 channel blockers increase the peristaltic activity of guinea-pig ileum by stimulating acetylcholine and tachykinins release by the enteric nervous system" @default.
• W2007992968 cites W1494926748 @default.
• W2007992968 cites W1555733423 @default.
• W2007992968 cites W1558096813 @default.
• W2007992968 cites W1904956466 @default.
• W2007992968 cites W1966644204 @default.
• W2007992968 cites W1976595515 @default.
• W2007992968 cites W2008241080 @default.
• W2007992968 cites W2008543342 @default.
• W2007992968 cites W2008868238 @default.
• W2007992968 cites W2024608183 @default.
• W2007992968 cites W2032708250 @default.
• W2007992968 cites W2034063579 @default.
• W2007992968 cites W2041673753 @default.
• W2007992968 cites W2047922613 @default.
• W2007992968 cites W2050733735 @default.
• W2007992968 cites W2066934511 @default.
• W2007992968 cites W2079360716 @default.
• W2007992968 cites W2086922185 @default.
• W2007992968 cites W2090315777 @default.
• W2007992968 cites W2106451614 @default.
• W2007992968 cites W2165109950 @default.
• W2007992968 cites W2185280366 @default.
• W2007992968 cites W2280517605 @default.
• W2007992968 cites W4241422053 @default.
• W2007992968 doi "https://doi.org/10.1038/sj.bjp.0705023" @default.
• W2007992968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1573649" @default.
• W2007992968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12522073" @default.
• W2007992968 hasPublicationYear "2003" @default.
• W2007992968 type Work @default.
• W2007992968 sameAs 2007992968 @default.
• W2007992968 citedByCount "14" @default.
• W2007992968 countsByYear W20079929682013 @default.
• W2007992968 countsByYear W20079929682014 @default.
• W2007992968 countsByYear W20079929682016 @default.
• W2007992968 countsByYear W20079929682023 @default.
• W2007992968 crossrefType "journal-article" @default.
• W2007992968 hasAuthorship W2007992968A5007963409 @default.
• W2007992968 hasAuthorship W2007992968A5026860985 @default.
• W2007992968 hasAuthorship W2007992968A5042514932 @default.
• W2007992968 hasAuthorship W2007992968A5074411363 @default.
• W2007992968 hasAuthorship W2007992968A5077113337 @default.
• W2007992968 hasBestOaLocation W20079929682 @default.
• W2007992968 hasConcept C126322002 @default.
• W2007992968 hasConcept C134018914 @default.
• W2007992968 hasConcept C170493617 @default.
• W2007992968 hasConcept C185592680 @default.
• W2007992968 hasConcept C206813253 @default.
• W2007992968 hasConcept C2775859210 @default.
• W2007992968 hasConcept C2775910092 @default.
• W2007992968 hasConcept C2776919887 @default.
• W2007992968 hasConcept C2777226302 @default.
• W2007992968 hasConcept C2777439022 @default.
• W2007992968 hasConcept C2780419564 @default.
• W2007992968 hasConcept C33789571 @default.
• W2007992968 hasConcept C55493867 @default.
• W2007992968 hasConcept C71924100 @default.
• W2007992968 hasConcept C83743174 @default.
• W2007992968 hasConcept C86803240 @default.
• W2007992968 hasConcept C98274493 @default.
• W2007992968 hasConceptScore W2007992968C126322002 @default.
• W2007992968 hasConceptScore W2007992968C134018914 @default.
• W2007992968 hasConceptScore W2007992968C170493617 @default.
• W2007992968 hasConceptScore W2007992968C185592680 @default.
• W2007992968 hasConceptScore W2007992968C206813253 @default.
• W2007992968 hasConceptScore W2007992968C2775859210 @default.
• W2007992968 hasConceptScore W2007992968C2775910092 @default.
• W2007992968 hasConceptScore W2007992968C2776919887 @default.
• W2007992968 hasConceptScore W2007992968C2777226302 @default.
• W2007992968 hasConceptScore W2007992968C2777439022 @default.
• W2007992968 hasConceptScore W2007992968C2780419564 @default.
• W2007992968 hasConceptScore W2007992968C33789571 @default.
• W2007992968 hasConceptScore W2007992968C55493867 @default.
• W2007992968 hasConceptScore W2007992968C71924100 @default.
• W2007992968 hasConceptScore W2007992968C83743174 @default.
• W2007992968 hasConceptScore W2007992968C86803240 @default.
• W2007992968 hasConceptScore W2007992968C98274493 @default.
• W2007992968 hasIssue "1" @default.
• W2007992968 hasLocation W20079929681 @default.
• W2007992968 hasLocation W20079929682 @default.
• W2007992968 hasLocation W20079929683 @default.
• W2007992968 hasLocation W20079929684 @default.
• W2007992968 hasOpenAccess W2007992968 @default.
• W2007992968 hasPrimaryLocation W20079929681 @default.
• W2007992968 hasRelatedWork W1975755678 @default.
• W2007992968 hasRelatedWork W2007992968 @default.
• W2007992968 hasRelatedWork W2013612570 @default.
• W2007992968 hasRelatedWork W2016371017 @default.
• W2007992968 hasRelatedWork W2063741409 @default.

• next