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- W2007993876 abstract "Pyrimidine dimers were measured in epidermal DNA of SKH:HRI mice following exposure to solar-simulated UV radiation (SSUV, 290–400 nm) or to UVA (320–400 nm). Mice were exposed to SSUV or UVA after topical application (2 mg/cm2) of vehicle, a UVB absorber (5% 2-ethylhexyl p-methoxycinnamate [2-EHMC]), or a broad-spectrum UVA absorber (5% Mexoryl®SX). The rates of induction of pyrimidine dimers in untreated animals were 5.4 ± 0.57 times 10-4 (mean ± SEM) and 7.6 ± 0.95 times 10-6 dimers per 108 Da of epidermal DNA per J/m2 of SSUV and UVA, respectively. Topical application of Mexoryl®SX reduced the rate of induction of pyrimidine dimers in SSUV-exposed animals to 4.7 ± 0.44 times 10-5 dimers per 108 Da per J/m2 for a dimer induction protection factor (PF) of 11.5 (5.4 times 10 4/4.7 times 10-5). The rate of dimer induction in Mexoryl®SX-treated, UVA-ex-posed mice was 0.95 ± 0.2 times 10-6 dimers per 108 Da per J/m2 (PF = 8.0). The 2-EHMC at a concentration of 5% (wt/wt) was significantly less effective than Mexoryl®SX in preventing the induction of pyrimidine dimers in animals exposed to either SSUV or UVA. The rates of dimer induction in 2-EHMC-treated mice were 8.2 ± 1.1 times 10-5 and 3.8 ± 0.33 times 10-6 dimers per Da per J/m2 of SSUV (PF = 6.6) and UVA (PF = 2.0), respectively. Upon normalizing to the efficacy for edema induction, UVA induced approximately one-fourth the number of pyrimidine dimers per equivalent edematous response when compared to SSUV." @default.
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- W2007993876 title "Sunscreen Protection Against Ultraviolet Radiation-induced Pyrimidine Dimers in Mouse Epidermal DNA" @default.
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- W2007993876 doi "https://doi.org/10.1111/j.1751-1097.1997.tb07961.x" @default.
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