FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007994504> ?p ?o ?g. }

• W2007994504 endingPage "597" @default.
• W2007994504 startingPage "590" @default.
• W2007994504 abstract "A structure-activity relationship for bile acid (BA) intestinal absorption is known to exist. To better understand the BA structural requirements for optimal BA intestinal absorption, rabbit ileal perfusion studies were performed. Unconjugated BA: Ursodeoxycholic (UDCA) and ursocholic acid (UCA) with methyl (6MUDCA and 6MUCA) or fluoro group (6FUDCA and 6FUCA) in the 6 position and UCA with a methyl group in 23 position (23MUCA) were compared with unconjugated UDCA, UCA, deoxycholic (DCA), chenodeoxycholic (CDCA), hyocholic (HCA), and hyodeoxycholic (HDCA) acid, BA lipophilicity was evaluated by their octanol-water partition coefficient. Conjugated BA: Taurine-conjugated UDCA and UCA with a methyl group in the 23 position (T23MUDCA and T23MUCA) were compared with the corresponding taurine-conjugated natural analogs. An analog of glycine-conjugated UDCA with the C24 amide bond replaced by a -CO-CH2- in the 24 position (24PUDCA) was studied and results were compared with the natural form (GUDCA). Unconjugated BA absorption was dose dependent (i.e., passive) and followed their lipophilicity: DCA > 6MUDCA > CDCA > HDCA > UDCA > HCA > 6FUDCA > 6MUCA > 6FUCA > UCA. Conjugated BA absorption was active, and Vmax was in the following order: TCA > TUDCA > TUCA > T23MUCA > T23MUDCA > 24PUDCA > GUDCA. 24PUDCA transport was also active and higher than GUDCA. Conclusion: Passive transport is dependent on BA lipophilicity. Conjugated BAs are actively transported, and the presence of a 23-C methyl group does not improve transport when compared with the natural analogs. The substitution of the C24 amide bond with a -CO-CH2- still affords interaction of the BA with the intestinal transport carrier." @default.
• W2007994504 created "2016-06-24" @default.
• W2007994504 creator A5009365625 @default.
• W2007994504 creator A5017477927 @default.
• W2007994504 creator A5030701699 @default.
• W2007994504 creator A5033420164 @default.
• W2007994504 creator A5045044750 @default.
• W2007994504 creator A5066270284 @default.
• W2007994504 date "1996-10-01" @default.
• W2007994504 modified "2023-10-18" @default.
• W2007994504 title "Relationship between structure and intestinal absorption of bile acids with a steroid or side-chain modification" @default.
• W2007994504 cites W1487213872 @default.
• W2007994504 cites W1509191323 @default.
• W2007994504 cites W1539287055 @default.
• W2007994504 cites W1564906832 @default.
• W2007994504 cites W1603127702 @default.
• W2007994504 cites W1623822643 @default.
• W2007994504 cites W1875161787 @default.
• W2007994504 cites W1965984516 @default.
• W2007994504 cites W1971971855 @default.
• W2007994504 cites W1976479023 @default.
• W2007994504 cites W1978879848 @default.
• W2007994504 cites W1986362315 @default.
• W2007994504 cites W1986754784 @default.
• W2007994504 cites W2003418739 @default.
• W2007994504 cites W2019349041 @default.
• W2007994504 cites W2029285720 @default.
• W2007994504 cites W2036924320 @default.
• W2007994504 cites W2057212498 @default.
• W2007994504 cites W2081494910 @default.
• W2007994504 cites W2088098389 @default.
• W2007994504 cites W2093256451 @default.
• W2007994504 cites W2121848003 @default.
• W2007994504 cites W2134192648 @default.
• W2007994504 cites W2144397336 @default.
• W2007994504 cites W2146017274 @default.
• W2007994504 cites W2166665362 @default.
• W2007994504 cites W2340020058 @default.
• W2007994504 cites W2382053180 @default.
• W2007994504 cites W2396587748 @default.
• W2007994504 doi "https://doi.org/10.1016/s0039-128x(96)00119-5" @default.
• W2007994504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8910972" @default.
• W2007994504 hasPublicationYear "1996" @default.
• W2007994504 type Work @default.
• W2007994504 sameAs 2007994504 @default.
• W2007994504 citedByCount "34" @default.
• W2007994504 countsByYear W20079945042012 @default.
• W2007994504 countsByYear W20079945042013 @default.
• W2007994504 countsByYear W20079945042014 @default.
• W2007994504 countsByYear W20079945042016 @default.
• W2007994504 countsByYear W20079945042018 @default.
• W2007994504 countsByYear W20079945042019 @default.
• W2007994504 countsByYear W20079945042020 @default.
• W2007994504 countsByYear W20079945042021 @default.
• W2007994504 countsByYear W20079945042022 @default.
• W2007994504 crossrefType "journal-article" @default.
• W2007994504 hasAuthorship W2007994504A5009365625 @default.
• W2007994504 hasAuthorship W2007994504A5017477927 @default.
• W2007994504 hasAuthorship W2007994504A5030701699 @default.
• W2007994504 hasAuthorship W2007994504A5033420164 @default.
• W2007994504 hasAuthorship W2007994504A5045044750 @default.
• W2007994504 hasAuthorship W2007994504A5066270284 @default.
• W2007994504 hasConcept C112613896 @default.
• W2007994504 hasConcept C121332964 @default.
• W2007994504 hasConcept C125287762 @default.
• W2007994504 hasConcept C178790620 @default.
• W2007994504 hasConcept C185592680 @default.
• W2007994504 hasConcept C201399114 @default.
• W2007994504 hasConcept C24890656 @default.
• W2007994504 hasConcept C2778439535 @default.
• W2007994504 hasConcept C2779399885 @default.
• W2007994504 hasConcept C2779701627 @default.
• W2007994504 hasConcept C2780749602 @default.
• W2007994504 hasConcept C2780965833 @default.
• W2007994504 hasConcept C515207424 @default.
• W2007994504 hasConcept C521977710 @default.
• W2007994504 hasConcept C55493867 @default.
• W2007994504 hasConcept C71240020 @default.
• W2007994504 hasConceptScore W2007994504C112613896 @default.
• W2007994504 hasConceptScore W2007994504C121332964 @default.
• W2007994504 hasConceptScore W2007994504C125287762 @default.
• W2007994504 hasConceptScore W2007994504C178790620 @default.
• W2007994504 hasConceptScore W2007994504C185592680 @default.
• W2007994504 hasConceptScore W2007994504C201399114 @default.
• W2007994504 hasConceptScore W2007994504C24890656 @default.
• W2007994504 hasConceptScore W2007994504C2778439535 @default.
• W2007994504 hasConceptScore W2007994504C2779399885 @default.
• W2007994504 hasConceptScore W2007994504C2779701627 @default.
• W2007994504 hasConceptScore W2007994504C2780749602 @default.
• W2007994504 hasConceptScore W2007994504C2780965833 @default.
• W2007994504 hasConceptScore W2007994504C515207424 @default.
• W2007994504 hasConceptScore W2007994504C521977710 @default.
• W2007994504 hasConceptScore W2007994504C55493867 @default.
• W2007994504 hasConceptScore W2007994504C71240020 @default.
• W2007994504 hasIssue "10" @default.
• W2007994504 hasLocation W20079945041 @default.
• W2007994504 hasLocation W20079945042 @default.
• W2007994504 hasOpenAccess W2007994504 @default.

• next