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• W2007995027 abstract "Abstract Cerebral cavernous malformation (CCM) involves the homozygous inactivating mutations of one of three genes, ccm1 , -2 , or -3 resulting in hyperpermeable blood vessels in the brain. The CCM1, -2, and -3 proteins form a complex to organize the signaling networks controlling endothelial cell physiology including actin dynamics, tube formation, and adherens junctions. The common biochemical defect with the loss of CCM1, -2, or -3 is increased RhoA activity leading to the activation of Rho-associated coiled coil-forming kinase (ROCK). Inhibition of the ROCK rescues CCM endothelial cell dysfunction, suggesting that the inhibition of RhoA-ROCK signaling may be a therapeutic strategy to prevent or arrest the progression of the CCM lesions." @default.
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• W2007995027 date "2012-12-04" @default.
• W2007995027 modified "2023-10-01" @default.
• W2007995027 title "Cerebral cavernous malformation is a vascular disease associated with activated RhoA signaling" @default.
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• W2007995027 doi "https://doi.org/10.1515/hsz-2012-0243" @default.
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