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- W2007995959 abstract "To the Editor: Maintenance hemodialysis patients with end-stage renal disease have an increased incidence of renal cell carcinoma compared with the general population1Iseki K. Osawa A. Fukiyama K. Evidence for increased cancer deaths in chronic dialysis patients.Am J Kidney Dis. 1993; 22: 308-313Abstract Full Text PDF PubMed Scopus (65) Google Scholar. Since the pathogenic mechanisms responsible for the increased renal cell carcinoma in maintenance hemodialysis patients have not been fully elucidated, it is worth understanding the carcinogenic process to establish new diagnostic and preventive procedures for renal cell carcinoma. We reported that connexin genes, a member of gap junction, act as a tumor suppressor with certain specificity2Yano T. Hernandez-Blazques F.J. Omori Y. Yamasaki H. Reduction of malignant phenotype of HepG2 cell is associated with the expression of connexin 26 but not connexin 32.Carcinogenesis. 2001; 22: 1593-1600Crossref PubMed Scopus (83) Google Scholar,3Yamasaki H. Omori Y. Krutovskikh V. et al.Connexins in tumour suppression and cancer therapy.Novartis Found Symp. 1999; 219: 241-254PubMed Google Scholar. That is, connexin preferentially exerts a tumor-suppressive effect on the tumor different from normal progenitor cells in which the particular connexin gene is naturally expressed. Thus, to clarify the exact role of the connexin gene as a tumor-suppressor gene in each tissue, it is necessary to determine the connexin subtype specifically expressed in the progenitor cell of each tumor. Recently, we showed that connexin 32 is specifically down-regulated in renal cell carcinoma from maintenance hemodialysis patients and several renal carcinoma cells established from the maintenance hemodialysi patients4YANO T. MESNIL M. YAMASAKI H. Study on the role of connexin genes as tumor suppressor and development of a new cancer therapy mediated by the genes.2002 Report of Japan Human Sciences Foundation. 2002: 64-68Google Scholar. On the other hand, we confirmed that human renal proximal tubular cell (a progenitor cell of renal cell carcinoma) and noncancerous regions of kidneys from maintenance hemodialysis patients have the expression of connexin 32. Furthermore, we found that the recovery of the expression of connexin 32 in the renal carcinoma cells reduced some malignant phenotypes of the cells. These results suggest that connexin 32 acts as a tumor suppressor against renal cell carcinoma from mainenance hemodialysis patients. Overall, maintaining the expression of connexin 32 during the development of renal cell carcinoma in maintenance hemodialysis patients may be a preventive procedure for the occurrence of renal cell carcinoma." @default.
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- W2007995959 date "2003-01-01" @default.
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- W2007995959 title "Tumor-suppressive effect of connexin 32 in renal cell carcinoma from maintenance hemodialysis patients" @default.
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- W2007995959 doi "https://doi.org/10.1046/j.1523-1755.2003.00745.x" @default.
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