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• W2008004857 abstract "Our aim was to clarify the association of human papillomavirus (HPV) with oral carcinogenesis, especially its early stage.Tissue specimens of normal mucosa, epithelial dysplasia, oral squamous cell carcinoma (OSCC), and OSCC cell lines were examined for the presence of HPV-16 and HPV-18 E6 DNA by means of the polymerase chain reaction test.The detection rate of HPV-16 in epithelial dysplasia (31/51) was higher than that in normal mucosa (16/44) and in OSCC (30/86) and was statistically different from that in OSCC. The cases that progressed from epithelial dysplasia to carcinoma showed a significantly higher HPV-16 detection rate than the other cases in both epithelial dysplasia and OSCC. HPV-16 and HPV-18 were detected only at early passages of 2 of 10 OSCC cell lines.These results strongly suggest that HPV-16 may be involved in the early stages of the development of some oral carcinomas." @default.
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• W2008004857 date "2003-05-01" @default.
• W2008004857 modified "2023-09-25" @default.
• W2008004857 title "Detection of human papillomavirus-16 and HPV-18 DNA in normal, dysplastic, and malignant oral epithelium" @default.
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• W2008004857 doi "https://doi.org/10.1067/moe.2003.36" @default.
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