Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008009741> ?p ?o ?g. }
- W2008009741 abstract "Unexpectedly, lithiation of N'-(2-(2-methylphenyl)ethyl)-N,N-dimethylurea with 3 equiv of n-butyllithium in anhydrous THF at 0 °C takes place on the nitrogen and on the CH(2) next to the 2-methylphenyl ring (α-lithiation). The lithium reagent thus obtained reacts with various electrophiles to give the corresponding substituted derivatives in excellent yields. Similarly, lithiation of N-(2-(2-methylphenyl)ethyl)pivalamide under similar reaction conditions followed by reaction with benzophenone as a representative electrophile gave the corresponding α-substituted product in high yield. Surprisingly, no products resulting from lateral lithiation were observed under the conditions tried, which sharply contrasts with the reported results for lateral lithiation of tert-butyl (2-(2-methylphenyl)ethyl)carbamate." @default.
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- W2008009741 date "2012-12-10" @default.
- W2008009741 modified "2023-09-23" @default.
- W2008009741 title "Variation in the Site of Lithiation of 2-(2-Methylphenyl)ethanamine Derivatives" @default.
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- W2008009741 doi "https://doi.org/10.1021/jo3023445" @default.
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