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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008014544> ?p ?o ?g. }

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• W2008014544 abstract "A series of novel 2-methoxy-phenyl dimethyl-carbamate derivatives were designed, synthesized and evaluated as site-activated MTDLs based on rivastigmine and curcumin. Most of them exhibited good to excellent AChE and BuChE inhibitory activities with sub-micromolar IC50 values. Among all the compounds, 6a demonstrated the most potent AChE inhibition with IC50 value of 0.097 μM, which is about 20-fold than that of rivastigmine. In addition, the three selected compounds 5a, 6a and 6e demonstrated inhibitory activity against Aβ self-aggregation similar to cucurmin in TEM assay, which is obviously different from the weak activity of rivastigmine. Moreover, the hydrolysate of 6a (compound 7) also showed potent ABTS+ scavenging and moderate copper ion chelating activity in vitro." @default.
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• W2008014544 date "2014-09-01" @default.
• W2008014544 modified "2023-10-14" @default.
• W2008014544 title "Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer’s disease therapy" @default.
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• W2008014544 doi "https://doi.org/10.1016/j.bmc.2014.07.009" @default.
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