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- W2008018458 abstract "MoAb can be labeled with I-123 at high specific activities, so that only small amounts of protein are required for injection of large amounts of radioactivity for radioimmunoimaging or radioimmunotherapy. This can conserve antibody and decrease the possibilities of foreign protein reactions and target tissue binding site saturation. However, some investigators have suggested the use of milligram quantities of MoAb. In order to assess the effects on pharmacokinetics and imaging, we have administered microgram or milligram amounts of MoAb on separate occasions to 2 patients with a target tumor and 2 patients without a target tumor. Pharmacokinetics were observed in blood and urine by counting whole samples and HPLC fractions of these samples and in organs by serial imaging. Blood clearance and urinary excretion were faster during the early hours after injection of microgram amounts of MoAb, but subsequently were comparable to those obtained after milligram amounts. HPLC revealed rapid accumulation of radioiodide in the blood after microgram amounts, whereas the rate of accumulation and amount of radioiodide were less after milligram amounts. Complexes occurred earlier after milligram and later after microgram amounts of MoAb. Images confirmed rapid clearance of accumulation in stomach, thyroid and bladder. When a target cancer was present, there was also relatively greater activity in the lungs with microgram MoAb amounts compared to milligram amounts. This was not true in the absence of a target cancer. These observations have significant, but as yet, incompletely clear implications for radioimmunoimaging and radioimmunotherapy." @default.
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- W2008018458 date "1984-09-01" @default.
- W2008018458 modified "2023-09-26" @default.
- W2008018458 title "EFFECTS OF PROTEIN MASS ON THE PHARMACOKINETICS OF MONOCLONAL ANTIBODIES (MoAb)" @default.
- W2008018458 doi "https://doi.org/10.1097/00003072-198409001-00032" @default.
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