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- W2008020964 abstract "Schizophrenia is a severe mental disorder associated with a characteristic constellation of symptoms and neurocognitive deficits. At present, etiological mechanisms remain relatively unknown, although multiple points of convergence have been identified over recent years. One of the primary convergence points is dysfunction of N-methyl-d-aspartate (NMDAR)-type glutamate receptors. Antagonists of NMDAR produce a clinical syndrome that closely resembles, and uniquely incorporates negative and cognitive symptoms of schizophrenia, along with the specific pattern of neurocognitive dysfunction seen in schizophrenia. Genetic polymorphisms involving NMDAR subunits, particularly the GRIN2B subunit have been described. In addition, polymorphisms have been described in modulatory systems involving the NMDAR, including the enzymes serine racemase and d-amino acid oxidase/G72 that regulate brain d-serine synthesis. Reductions in plasma and brain glycine, d-serine and glutathione levels have been described as well, providing potential mechanisms underlying NMDAR dysfunction. Unique characteristics of the NMDAR are described that may explain the characteristic pattern of symptoms and neurocognitive deficits observed in schizophrenia. Finally, the NMDAR complex represents a convergence point for potential new treatment approaches in schizophrenia aimed at correcting underlying abnormalities in synthesis and regulation of allosteric modulators, as well as more general potentiation of pre- and post-synaptic glutamatergic and NMDAR function." @default.
- W2008020964 created "2016-06-24" @default.
- W2008020964 creator A5008479872 @default.
- W2008020964 creator A5045818277 @default.
- W2008020964 date "2010-09-01" @default.
- W2008020964 modified "2023-10-03" @default.
- W2008020964 title "N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: The final common pathway on the road to schizophrenia?" @default.
- W2008020964 cites W1507804974 @default.
- W2008020964 cites W1518500152 @default.
- W2008020964 cites W1531783246 @default.
- W2008020964 cites W1575357711 @default.
- W2008020964 cites W1606744897 @default.
- W2008020964 cites W1794950817 @default.
- W2008020964 cites W1816320711 @default.
- W2008020964 cites W1852307392 @default.
- W2008020964 cites W1963479676 @default.
- W2008020964 cites W1963953482 @default.
- W2008020964 cites W1966480770 @default.
- W2008020964 cites W1968024448 @default.
- W2008020964 cites W1968584106 @default.
- W2008020964 cites W1968980690 @default.
- W2008020964 cites W1970448316 @default.
- W2008020964 cites W1975586101 @default.
- W2008020964 cites W1980582117 @default.
- W2008020964 cites W1980921457 @default.
- W2008020964 cites W1981359380 @default.
- W2008020964 cites W1981534919 @default.
- W2008020964 cites W1982163126 @default.
- W2008020964 cites W1985807703 @default.
- W2008020964 cites W1987285132 @default.
- W2008020964 cites W1987314032 @default.
- W2008020964 cites W1991661467 @default.
- W2008020964 cites W1995079626 @default.
- W2008020964 cites W1996141026 @default.
- W2008020964 cites W1996477167 @default.
- W2008020964 cites W1998461664 @default.
- W2008020964 cites W2000433175 @default.
- W2008020964 cites W2002331435 @default.
- W2008020964 cites W2003712515 @default.
- W2008020964 cites W2003906510 @default.
- W2008020964 cites W2004830149 @default.
- W2008020964 cites W2007492904 @default.
- W2008020964 cites W2008412902 @default.
- W2008020964 cites W2012641732 @default.
- W2008020964 cites W2013209042 @default.
- W2008020964 cites W2019130280 @default.
- W2008020964 cites W2020029019 @default.
- W2008020964 cites W2022211225 @default.
- W2008020964 cites W2023243449 @default.
- W2008020964 cites W2024697152 @default.
- W2008020964 cites W2024746554 @default.
- W2008020964 cites W2026348045 @default.
- W2008020964 cites W2026782090 @default.
- W2008020964 cites W2028884770 @default.
- W2008020964 cites W2029925498 @default.
- W2008020964 cites W2030137168 @default.
- W2008020964 cites W2032187584 @default.
- W2008020964 cites W2036691985 @default.
- W2008020964 cites W2037400256 @default.
- W2008020964 cites W2039017331 @default.
- W2008020964 cites W2039576727 @default.
- W2008020964 cites W2042585712 @default.
- W2008020964 cites W2044783071 @default.
- W2008020964 cites W2047427656 @default.
- W2008020964 cites W2048080687 @default.
- W2008020964 cites W2048405858 @default.
- W2008020964 cites W2048455378 @default.
- W2008020964 cites W2049335636 @default.
- W2008020964 cites W2051369940 @default.
- W2008020964 cites W2051829807 @default.
- W2008020964 cites W2052480734 @default.
- W2008020964 cites W2053842655 @default.
- W2008020964 cites W2053845575 @default.
- W2008020964 cites W2054153218 @default.
- W2008020964 cites W2055970280 @default.
- W2008020964 cites W2056372896 @default.
- W2008020964 cites W2056904033 @default.
- W2008020964 cites W2057207511 @default.
- W2008020964 cites W2058075954 @default.
- W2008020964 cites W2061506085 @default.
- W2008020964 cites W2061902128 @default.
- W2008020964 cites W2062355133 @default.
- W2008020964 cites W2063850678 @default.
- W2008020964 cites W2064059402 @default.
- W2008020964 cites W2064286037 @default.
- W2008020964 cites W2066583262 @default.
- W2008020964 cites W2067446209 @default.
- W2008020964 cites W2067501599 @default.
- W2008020964 cites W2069450207 @default.
- W2008020964 cites W2069849124 @default.
- W2008020964 cites W2070910425 @default.
- W2008020964 cites W2071199266 @default.
- W2008020964 cites W2071723486 @default.
- W2008020964 cites W2072877245 @default.
- W2008020964 cites W2073544062 @default.
- W2008020964 cites W2075033894 @default.
- W2008020964 cites W2076923795 @default.
- W2008020964 cites W2077609442 @default.