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• W2008023461 abstract "Summary We determined the occurrence of the single nucleotide polymorphisms (SNPs) −403A/G and −28C/G in the promoter region of RANTES in 1082 Chinese blood donors from northern and southern China and 249 HIV patients from southern China. Compared to healthy adults, Chinese AIDS patients had a significantly higher frequency of the −403G allele and haplotype I, −403G/−28C ( P < 0.05), and a lower frequency of the −403A/A genotype ( P < 0.01). Symptomatic patients had a higher frequency of the −28G allele and a lower frequency of the −28C/C genotype ( P ≤ 0.01). The plasma RANTES level was significantly lower in blood donors homozygous for haplotype I than in those who were homozygous for haplotypes II and III ( P < 0.05). The frequency of the −403G allele was found to be higher in Chinese than in indigenous Africans, but lower than in Caucasians, Hispanics, and African Americans. The frequency of the −28G allele was comparable in Chinese and Japanese; this allele is rare in other ethnic groups. Results suggest that −403G may be associated with increased susceptibility to HIV infection, while −28G may be associated with advanced disease progression. The impact of SNPs on HIV infection appears to be unique in Chinese." @default.
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• W2008023461 date "2004-07-09" @default.
• W2008023461 modified "2023-10-15" @default.
• W2008023461 title "Effects of single nucleotide polymorphisms in the RANTES promoter region in healthy and HIV-infected indigenous Chinese*" @default.
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• W2008023461 doi "https://doi.org/10.1111/j.1365-2370.2004.00466.x" @default.
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