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- W2008029817 abstract "Acetaminophen (AAP) overdose and the resulting hepatotoxicity is an important clinical problem. In addition, AAP is widely used as a prototype hepatotoxin to study mechanisms of chemical-induced cell injury and to test the hepatoprotective potential of new drugs and herbal medicines. Because of its importance, the mechanisms of AAP-induced liver cell injury have been extensively investigated and controversially discussed for > 30 years. This review highlights recent new insight into intracellular events critical for liver cell death. In addition, the relevance of the inflammatory response is addressed, including cytotoxic and inflammatory mediators generated by activated inflammatory cells, that is, resident macrophages and lymphocytes as well as newly recruited blood-derived leukocytes. Inflammation is a critical component of the overall pathophysiology, not only as a potential factor that may aggravate cell damage, but more importantly as a vital response to limit cell injury, remove cell debris and promote regeneration." @default.
- W2008029817 created "2016-06-24" @default.
- W2008029817 creator A5087156903 @default.
- W2008029817 date "2005-09-29" @default.
- W2008029817 modified "2023-09-25" @default.
- W2008029817 title "Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity" @default.
- W2008029817 cites W125488177 @default.
- W2008029817 cites W1482264334 @default.
- W2008029817 cites W1525487916 @default.
- W2008029817 cites W1574945736 @default.
- W2008029817 cites W1592028829 @default.
- W2008029817 cites W160522190 @default.
- W2008029817 cites W1860141269 @default.
- W2008029817 cites W1922918425 @default.
- W2008029817 cites W1953009759 @default.
- W2008029817 cites W1963565350 @default.
- W2008029817 cites W1964245692 @default.
- W2008029817 cites W1972156785 @default.
- W2008029817 cites W1972310964 @default.
- W2008029817 cites W1973441276 @default.
- W2008029817 cites W1975892042 @default.
- W2008029817 cites W1982552165 @default.
- W2008029817 cites W1983806295 @default.
- W2008029817 cites W1985662930 @default.
- W2008029817 cites W1986107319 @default.
- W2008029817 cites W1987092996 @default.
- W2008029817 cites W1989422775 @default.
- W2008029817 cites W1991353603 @default.
- W2008029817 cites W1991803130 @default.
- W2008029817 cites W1991844778 @default.
- W2008029817 cites W1995744241 @default.
- W2008029817 cites W2002427790 @default.
- W2008029817 cites W2003873847 @default.
- W2008029817 cites W2006161003 @default.
- W2008029817 cites W2006286083 @default.
- W2008029817 cites W2007154180 @default.
- W2008029817 cites W2007456787 @default.
- W2008029817 cites W2007837805 @default.
- W2008029817 cites W2008857800 @default.
- W2008029817 cites W2009162867 @default.
- W2008029817 cites W2009609856 @default.
- W2008029817 cites W2013340411 @default.
- W2008029817 cites W2013832046 @default.
- W2008029817 cites W2014833145 @default.
- W2008029817 cites W2018685529 @default.
- W2008029817 cites W2019197831 @default.
- W2008029817 cites W2019471671 @default.
- W2008029817 cites W2028071396 @default.
- W2008029817 cites W2031381742 @default.
- W2008029817 cites W2033132686 @default.
- W2008029817 cites W2033635345 @default.
- W2008029817 cites W2042645188 @default.
- W2008029817 cites W2043492787 @default.
- W2008029817 cites W2044012105 @default.
- W2008029817 cites W2055420058 @default.
- W2008029817 cites W2059663663 @default.
- W2008029817 cites W2061298493 @default.
- W2008029817 cites W2063337484 @default.
- W2008029817 cites W2063991756 @default.
- W2008029817 cites W2065540066 @default.
- W2008029817 cites W2069585529 @default.
- W2008029817 cites W2071276803 @default.
- W2008029817 cites W2073976519 @default.
- W2008029817 cites W2076494277 @default.
- W2008029817 cites W2080397970 @default.
- W2008029817 cites W2082885785 @default.
- W2008029817 cites W2085718426 @default.
- W2008029817 cites W2087996623 @default.
- W2008029817 cites W2090546037 @default.
- W2008029817 cites W2097582131 @default.
- W2008029817 cites W2099240214 @default.
- W2008029817 cites W2101733022 @default.
- W2008029817 cites W2108290804 @default.
- W2008029817 cites W2112884164 @default.
- W2008029817 cites W2121137038 @default.
- W2008029817 cites W2129354263 @default.
- W2008029817 cites W2133074559 @default.
- W2008029817 cites W2134586772 @default.
- W2008029817 cites W2145560274 @default.
- W2008029817 cites W2155970781 @default.
- W2008029817 cites W2156827860 @default.
- W2008029817 cites W2158501840 @default.
- W2008029817 cites W2161109243 @default.
- W2008029817 cites W2170859109 @default.
- W2008029817 cites W2203679692 @default.
- W2008029817 cites W2219970926 @default.
- W2008029817 cites W2255266097 @default.
- W2008029817 cites W2337103164 @default.
- W2008029817 cites W4233261555 @default.
- W2008029817 cites W4240962591 @default.
- W2008029817 cites W4251613563 @default.
- W2008029817 cites W4298997209 @default.
- W2008029817 cites W4313333714 @default.
- W2008029817 doi "https://doi.org/10.1517/17425255.1.3.389" @default.
- W2008029817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16863451" @default.
- W2008029817 hasPublicationYear "2005" @default.
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