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- W2008034572 abstract "Memory lymphocytic choriomeningitis virus (LCMV)-immune cytotoxic T-lymphocyte precursors (CTLp) can be stimulated to proliferate and to mediate specific cytotoxic activity following incubation with phorbol myristate acetate (PMA), calcium ionophore (CaI), and interleukin 2 (IL-2). This protocol can be used to selectively induce virus-specific CTL activity under both bulk culture and limiting dilution conditions, in the absence of added antigen. There is no concurrent stimulation of alloreactive CTLp. Proliferation of the effector Lyt-2+ population in medium containing PMA and Cal requires L3T4+ cells, which can be replaced by adding IL-2, and the development of cytotoxicity is totally IL-2 dependent. The LCMV-specific memory T cells are also characterized by the expression of the Pgp-1 (Ly24) glycoprotein. The availability of this marker, together with the capacity to selectively stimulate primed CTLp in the absence of antigen, should greatly facilitate the analysis of T-cell memory in virus infections." @default.
- W2008034572 created "2016-06-24" @default.
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- W2008034572 date "1988-05-01" @default.
- W2008034572 modified "2023-09-23" @default.
- W2008034572 title "Virus-specific memory T cells are Pgp-1+ and can be selectively activated with phorbol ester and calcium lonophore" @default.
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- W2008034572 doi "https://doi.org/10.1016/0008-8749(88)90026-3" @default.
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