FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008035816> ?p ?o ?g. }

• W2008035816 endingPage "2822" @default.
• W2008035816 startingPage "2813" @default.
• W2008035816 abstract "Background Theoretical models predict that optimal capacitance for implantable cardioverter-defibrillators (ICDs) is proportional to the time-dependent parameter of the strength-duration relationship. The hyperbolic model gives this relationship for average current in terms of the chronaxie (t c ). The exponential model gives the relationship for leading-edge current in terms of the membrane time constant (τ m ). We hypothesized that these models predict results of clinical studies of ICD capacitance if human time constants are used. Methods and Results We studied 12 patients with epicardial ICDs and 15 patients with transvenous ICDs. Defibrillation threshold (DFT) was determined for 120-μF monophasic capacitive-discharge pulses at pulse widths of 1.5, 3.0, 7.5, and 15 ms. To compare the predictions of the average-current versus leading-edge-current methods, we derived a new exponential average-current model. We then calculated individual patient time parameters for each model. Model predictions were validated by retrospective comparison with clinical crossover studies of small-capacitor and standard-capacitor waveforms. All three models provided a good fit to the data ( r 2 =.88 to .97, P <.001). Time constants were lower for transvenous pathways (53±7 Ω) than epicardial pathways (36±6 Ω) (t c , P <.001; average-current τ m , P =.002; leading-edge-current τ m , P <.06). For epicardial pathways, optimal capacitance was greater for either average-current model than for the leading-edge-current model ( P <.001). For transvenous pathways, optimal capacitance differed for all three models ( P <.001). All models provided a good correlation with the effect of capacitance on DFT in previous clinical studies: r 2 =.75 to .84, P <.003. For 90-μF, 120-μF, and 150-μF capacitors, predicted stored-energy DFTs were 3% to 8%, 8% to 16%, and 14% to 26% above that for the optimal capacitance. Conclusions Model predictions based on measured human cardiac-muscle time parameter have a good correlation with clinical studies of ICD capacitance. Most of the predicted reduction in DFT can be achieved with ≈90-μF capacitors." @default.
• W2008035816 created "2016-06-24" @default.
• W2008035816 creator A5020245549 @default.
• W2008035816 creator A5020934523 @default.
• W2008035816 creator A5024219388 @default.
• W2008035816 creator A5048644691 @default.
• W2008035816 date "1997-11-04" @default.
• W2008035816 modified "2023-10-06" @default.
• W2008035816 title "Application of Models of Defibrillation to Human Defibrillation Data" @default.
• W2008035816 cites W171407135 @default.
• W2008035816 cites W1968053720 @default.
• W2008035816 cites W1983841514 @default.
• W2008035816 cites W1993042214 @default.
• W2008035816 cites W2002069669 @default.
• W2008035816 cites W2056390760 @default.
• W2008035816 cites W2063004044 @default.
• W2008035816 cites W2067444959 @default.
• W2008035816 cites W2077813669 @default.
• W2008035816 cites W2081244750 @default.
• W2008035816 cites W2086498970 @default.
• W2008035816 cites W2088665891 @default.
• W2008035816 cites W2092889215 @default.
• W2008035816 cites W2121083525 @default.
• W2008035816 cites W2129965918 @default.
• W2008035816 cites W2130516000 @default.
• W2008035816 cites W2133196561 @default.
• W2008035816 cites W4235220652 @default.
• W2008035816 cites W4252325404 @default.
• W2008035816 cites W4253179458 @default.
• W2008035816 doi "https://doi.org/10.1161/01.cir.96.9.2813" @default.
• W2008035816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9386143" @default.
• W2008035816 hasPublicationYear "1997" @default.
• W2008035816 type Work @default.
• W2008035816 sameAs 2008035816 @default.
• W2008035816 citedByCount "46" @default.
• W2008035816 countsByYear W20080358162012 @default.
• W2008035816 countsByYear W20080358162013 @default.
• W2008035816 countsByYear W20080358162014 @default.
• W2008035816 countsByYear W20080358162016 @default.
• W2008035816 countsByYear W20080358162017 @default.
• W2008035816 countsByYear W20080358162019 @default.
• W2008035816 countsByYear W20080358162021 @default.
• W2008035816 crossrefType "journal-article" @default.
• W2008035816 hasAuthorship W2008035816A5020245549 @default.
• W2008035816 hasAuthorship W2008035816A5020934523 @default.
• W2008035816 hasAuthorship W2008035816A5024219388 @default.
• W2008035816 hasAuthorship W2008035816A5048644691 @default.
• W2008035816 hasConcept C119599485 @default.
• W2008035816 hasConcept C121332964 @default.
• W2008035816 hasConcept C126322002 @default.
• W2008035816 hasConcept C127413603 @default.
• W2008035816 hasConcept C134306372 @default.
• W2008035816 hasConcept C148043351 @default.
• W2008035816 hasConcept C151376022 @default.
• W2008035816 hasConcept C162307627 @default.
• W2008035816 hasConcept C164705383 @default.
• W2008035816 hasConcept C17525397 @default.
• W2008035816 hasConcept C2777795826 @default.
• W2008035816 hasConcept C2778002379 @default.
• W2008035816 hasConcept C2982819079 @default.
• W2008035816 hasConcept C30066665 @default.
• W2008035816 hasConcept C33923547 @default.
• W2008035816 hasConcept C41008148 @default.
• W2008035816 hasConcept C46141821 @default.
• W2008035816 hasConcept C52859227 @default.
• W2008035816 hasConcept C62520636 @default.
• W2008035816 hasConcept C71924100 @default.
• W2008035816 hasConcept C76155785 @default.
• W2008035816 hasConcept C81370116 @default.
• W2008035816 hasConcept C97355855 @default.
• W2008035816 hasConceptScore W2008035816C119599485 @default.
• W2008035816 hasConceptScore W2008035816C121332964 @default.
• W2008035816 hasConceptScore W2008035816C126322002 @default.
• W2008035816 hasConceptScore W2008035816C127413603 @default.
• W2008035816 hasConceptScore W2008035816C134306372 @default.
• W2008035816 hasConceptScore W2008035816C148043351 @default.
• W2008035816 hasConceptScore W2008035816C151376022 @default.
• W2008035816 hasConceptScore W2008035816C162307627 @default.
• W2008035816 hasConceptScore W2008035816C164705383 @default.
• W2008035816 hasConceptScore W2008035816C17525397 @default.
• W2008035816 hasConceptScore W2008035816C2777795826 @default.
• W2008035816 hasConceptScore W2008035816C2778002379 @default.
• W2008035816 hasConceptScore W2008035816C2982819079 @default.
• W2008035816 hasConceptScore W2008035816C30066665 @default.
• W2008035816 hasConceptScore W2008035816C33923547 @default.
• W2008035816 hasConceptScore W2008035816C41008148 @default.
• W2008035816 hasConceptScore W2008035816C46141821 @default.
• W2008035816 hasConceptScore W2008035816C52859227 @default.
• W2008035816 hasConceptScore W2008035816C62520636 @default.
• W2008035816 hasConceptScore W2008035816C71924100 @default.
• W2008035816 hasConceptScore W2008035816C76155785 @default.
• W2008035816 hasConceptScore W2008035816C81370116 @default.
• W2008035816 hasConceptScore W2008035816C97355855 @default.
• W2008035816 hasIssue "9" @default.
• W2008035816 hasLocation W20080358161 @default.
• W2008035816 hasLocation W20080358162 @default.
• W2008035816 hasOpenAccess W2008035816 @default.
• W2008035816 hasPrimaryLocation W20080358161 @default.

• next