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- W2008043417 abstract "Although rheumatic heart disease is a rare complication of group A β-hemolytic streptococcal (GAS) pharyngitis in developed nations, it remains the most common cause of heart disease worldwide. This randomized control trial sought to assess non-inferiority of once-daily oral amoxicillin to intramuscular benzathine penicillin G (IM BPG) in successful eradication of GAS. After having a positive rapid streptococcal antigen detection test, children from 2 to 12 years of age in two urban clinics in Egypt and Croatia were randomized 1:1 to receive single-dose IM BPG or oral amoxicillin suspension once daily for 10 days. A total of 558 children (Croatia = 166, Egypt = 392) were randomized, of which 272 completed the study per protocol (PP), whereas the other 272 were evaluated in intention-to-treat (ITT) analysis. In Croatia, ITT and PP success rates were comparable for IM BPG and amoxicillin (2.5% difference vs. 1.1% difference, respectively). In Egypt, the two treatments were comparable in PP analysis (−9.3%), however, amoxicillin was not comparable to IM BPG in the ITT group (15.1% difference). In this study, when patients were compliant with either treatment eradication, success rates were equivalent. However, in Egypt, where compliance with the 10-day oral amoxicillin treatment was a major issue, the IM BPG treatment was superior in successful treatment of GAS pharyngitis." @default.
- W2008043417 created "2016-06-24" @default.
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- W2008043417 date "2011-11-01" @default.
- W2008043417 modified "2023-10-18" @default.
- W2008043417 title "Treatment of Streptococcal Pharyngitis with Once-Daily Amoxicillin versus Intramuscular Benzathine Penicillin G in Low-Resource Settings: A Randomized Control Trial" @default.
- W2008043417 doi "https://doi.org/10.1016/j.jemermed.2011.09.021" @default.
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