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• W2008043456 abstract "You have accessJournal of UrologyBladder Cancer: Detection & Screening1 Apr 2014MP22-19 HIGH NEGATIVE PREDICTIVE VALUE OF A CYTOGENETICALLY NORMAL BARBOTAGE (CNB) FISH IN PREDICTING BLADDER CANCER NON-RECURRENCE Eric Andresen, Daniel Lee, and Michael O'Donnell Eric AndresenEric Andresen More articles by this author , Daniel LeeDaniel Lee More articles by this author , and Michael O'DonnellMichael O'Donnell More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.867AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Urovysion’s FISH analysis is used to monitor bladder cancer recurrence in patients with a history of non-muscle invasive bladder cancer (NMIBC). However, the efficiency and use of a cytogenetically normal FISH obtained by saline barbotage wash has not been previously studied. The purpose of the study is to investigate whether a CNB FISH can be used to predict continued tumor free follow-up for patients with a history of NMIBC. METHODS A retrospective chart review identified a cohort of 241 consecutive patients who were diagnosed with NMIBC from 2002 to 2008. We reviewed all of the FISH samples obtained from these patients during their follow-up visits. 344 total FISH analyses were identified in the cohort that had 3-month post-analysis cystoscopy and cytology. Of those, 165 were cytogenetically normal. We also identified 177 CNB FISH analyses that were followed at 6 months by a cystoscopy/cytology. Only FISH samples that were reported as completely cytogenetically normal (0/50 abnormal cells per sample) were included. Tumor recurrence was defined as either high-grade cytology and/or presence of tumor found during cystoscopy. If tumor was present, the pathology was noted whenever possible. RESULTS Of the 165 CNB FISH analyses with a corresponding 3-month follow-up, 96.36% remained recurrence free (159/165). All recurrences at 3 months were identified by cystoscopy. Pathology from these patients were Ta high-grade (HG) - (2/6), indeterminate (2/6), Ta low-grade (LG) - (1/6) and bladder adenocarcinoma (1/6). Of the 177 FISH analyses with a corresponding 6-month follow-up, 93.79% of the patients were recurrence free (166/177). Recurrences were identified by cystoscopy (8/11) and cytology (3/11). Pathology for these cystoscopic recurrences included TaHG (1/8), TaLG (6/8), and indeterminate (1/8). All visible tumors were described as “small papillary lesions”. The three high-grade cytologies were eventually found to be bladder CIS. CONCLUSIONS Our data supports that a CNB FISH is highly predictive of tumor free status at both 3 and 6 months, missing primarily small, low-stage papillary recurrences. A CNB FISH analysis may have value as an adjunct to cystoscopy and cytology for monitoring bladder cancer. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e242 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Eric Andresen More articles by this author Daniel Lee More articles by this author Michael O'Donnell More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2008043456 title "MP22-19 HIGH NEGATIVE PREDICTIVE VALUE OF A CYTOGENETICALLY NORMAL BARBOTAGE (CNB) FISH IN PREDICTING BLADDER CANCER NON-RECURRENCE" @default.
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