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• W2008045642 abstract "We have previously reported that aerobic and resistance exercise training in breast cancer patients receiving chemotherapy is beneficial but the responses were heterogeneous. Researchers recommend that clinical trials should routinely conduct and report subgroup analyses to guide the next generation of studies and inform clinical practice. PURPOSE: To examine prespecified and exploratory moderators of the effects of exercise training in the Supervised Trial of Aerobic versus Resistance Training (START). METHODS: We conducted a multicenter randomized controlled trial in Canada between 2003 and 2005 that randomized 242 breast cancer patients initiating chemotherapy to usual care (n=82), resistance exercise (RET; n=82), or aerobic exercise (AET; n=78) for the duration of their chemotherapy. Our endpoints of interest were quality of life (QoL), physical fitness, and body composition. Our primary prespecified moderator analysis was patient preference on QoL. Secondary prespecified moderator analyses were age, disease stage, and chemotherapy regimen. Marital status was explored as a moderator of QoL. RESULTS: Patient preference (p for interaction=.003) and marital status (adjusted p for interaction=.039) moderated the effects of exercise training on QoL. Participants that preferred RET improved QoL more when assigned to RET and participants that had no preference improved QoL more when assigned to AET. Unmarried participants improved QoL with exercise training but married participants did not. Age moderated aerobic fitness changes (p for interaction=.015), chemotherapy regimen moderated muscular strength gains (p for interaction=.016), and disease stage moderated lean body mass gains (p for interaction<.001) and percent body fat change (adjusted p for interaction=.055). Younger participants, those receiving non-taxane-based chemotherapies, and those with more advanced disease stage experienced the better outcomes. The interactions were not explained by differences in exercise adherence. CONCLUSION: Patient preference moderated the effects of exercise training on QoL. Other important demographic and medical factors also altered exercise training responses. These results should be confirmed in future randomized trials and, if replicated, may inform clinical practice." @default.
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• W2008045642 date "2007-05-01" @default.
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• W2008045642 title "Moderators of the Effects of Exercise Training in Breast Cancer Patients Receiving Chemotherapy" @default.
• W2008045642 doi "https://doi.org/10.1249/01.mss.0000273148.93931.d3" @default.
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