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• W2008049248 abstract "Due to their key role in recognizing foreign antigens and triggering the subsequent immune response the genes of the major histocompatibility complex (MHC) provide a potential target for parasites to attack in order to evade detection and expulsion from the host. A diminished MHC gene expression results in less activated T cells and might serve as a gateway for pathogens and parasites. Some parasites are suspected to be immune suppressors and promote co-infections of other parasites even in other parts of the body. In our study we found indications that the gut dwelling nematode Heligmosomoides polygyrus might exert a systemic immunosuppressive effect in yellow-necked mice (Apodemus flavicollis). The amount of hepatic MHC class II DRB gene RNA transcripts in infected mice was negatively associated with infection intensity with H. polygyrus. The hepatic expression of immunosuppressive cytokines, such as transforming growth factor β and interleukin 10 was not associated with H. polygyrus infection. We did not find direct positive associations of H. polygyrus with other helminth species. But the prevalence and infection intensity of the nematodes Syphacia stroma and Trichuris muris were higher in multiple infected individuals. Furthermore, our data indicated antagonistic effects in the helminth community of A. flavicollis as cestode infection correlated negatively with H. polygyrus and helminth species richness. Our study shows that expression analyses of immune relevant genes can also be performed in wildlife, opening new aspects and possibilities for future ecological and evolutionary research." @default.
• W2008049248 created "2016-06-24" @default.
• W2008049248 creator A5000572560 @default.
• W2008049248 creator A5039483894 @default.
• W2008049248 date "2011-12-01" @default.
• W2008049248 modified "2023-09-25" @default.
• W2008049248 title "Heligmosomoides polygyrus infection is associated with lower MHC class II gene expression in Apodemus flavicollis: Indication for immune suppression?" @default.
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• W2008049248 doi "https://doi.org/10.1016/j.meegid.2011.09.020" @default.
• W2008049248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21983561" @default.
• W2008049248 hasPublicationYear "2011" @default.
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