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- W2008049411 abstract "Summary Primary prevention of cancer attempts to interrupt the complex causal pathway at the point of initiation or during the latent period when the initiated cells may be stimulated by promoting agents. However, the interaction of multiple environmental (exogenous) and host (endogenous) factors complicate the identification of carcinogens. Laboratory studies contribute, but extrapolation to humans may lead to error in risk assessment. However, when consistent, biologically plausible findings are observed among epidemiologic and experimental investigations, a causal relationship is supported. As we develop a better understanding of the mechanisms involved in initiation and promotion, more opportunities for intervention in the causal pathway may allow cancer prevention to be more readily achieved." @default.
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- W2008049411 date "1986-08-01" @default.
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- W2008049411 title "Assessment of carcinogenesis through epidemiologic and experimental investigations" @default.
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- W2008049411 doi "https://doi.org/10.1016/s0749-2081(86)80003-1" @default.
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