FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008054562> ?p ?o ?g. }

• W2008054562 endingPage "52" @default.
• W2008054562 startingPage "45" @default.
• W2008054562 abstract "We propose the name nucleotide pyrophosphatases/phosphodiesterases (NPP) for the enzymes that release nucleoside-5′-monophosphates from various pyrophosphate and phosphodiester bonds. Three structurally related mammalian NPPs are known, i.e. NPPα (autotaxin), NPPβ (B10/gp130RB13-6) and NPPγ (PC-1). We report here that these isozymes have a distinct tissue distribution in the rat but that they are all three expressed in hepatocytes. In FAO rat hepatoma cells only the level of NPPγ was stimulated by TGF-β1. In rat liver, the concentration of the transcripts of all three isozymes was found to increase manyfold during the first weeks after birth, but the increased expression of the NPPα mRNA was transient. The level of the NPP transcripts transiently decreased after hepatectomy, but NPPα mRNA was also lost after sham operation, which suggests that it may belong to the negative acute-phase proteins. The loss of the β- and γ-transcripts after hepatectomy was not due to a decreased NPP gene transcription or an increased turnover of the mature transcripts. However, hepatectomy also caused a similar loss of the nuclear pool of the NPPβ and NPPγ mRNAs. We conclude that a deficient processing and/or an increased turnover of the NPP pre-mRNAs underlies the hepatectomy-induced decrease of the β- and γ-transcripts. A similar loss of nuclear NPPγ mRNA was also noted after treatment with cycloheximide, indicating that protein(s) with a high turnover control the stability and/or processing of the immature NPPγ transcript." @default.
• W2008054562 created "2016-06-24" @default.
• W2008054562 creator A5011977039 @default.
• W2008054562 creator A5031719052 @default.
• W2008054562 creator A5064312456 @default.
• W2008054562 creator A5077673040 @default.
• W2008054562 date "1999-05-01" @default.
• W2008054562 modified "2023-09-25" @default.
• W2008054562 title "Differential regulation of the expression of nucleotide pyrophosphatases/phosphodiesterases in rat liver" @default.
• W2008054562 cites W1482279273 @default.
• W2008054562 cites W1734891090 @default.
• W2008054562 cites W1776095151 @default.
• W2008054562 cites W1873838517 @default.
• W2008054562 cites W1964136157 @default.
• W2008054562 cites W1972006668 @default.
• W2008054562 cites W1972233883 @default.
• W2008054562 cites W1972590507 @default.
• W2008054562 cites W1987337034 @default.
• W2008054562 cites W1992833199 @default.
• W2008054562 cites W1996463568 @default.
• W2008054562 cites W1998634392 @default.
• W2008054562 cites W2003744071 @default.
• W2008054562 cites W2014208767 @default.
• W2008054562 cites W2020170248 @default.
• W2008054562 cites W2040512444 @default.
• W2008054562 cites W2043392282 @default.
• W2008054562 cites W2052537158 @default.
• W2008054562 cites W2052561221 @default.
• W2008054562 cites W2060333964 @default.
• W2008054562 cites W2060541174 @default.
• W2008054562 cites W2079195476 @default.
• W2008054562 cites W2088562619 @default.
• W2008054562 cites W2130684966 @default.
• W2008054562 cites W2154746915 @default.
• W2008054562 cites W2170257664 @default.
• W2008054562 cites W2170335529 @default.
• W2008054562 cites W2254247617 @default.
• W2008054562 cites W302371127 @default.
• W2008054562 cites W4231922120 @default.
• W2008054562 doi "https://doi.org/10.1016/s0167-4889(99)00031-2" @default.
• W2008054562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10231554" @default.
• W2008054562 hasPublicationYear "1999" @default.
• W2008054562 type Work @default.
• W2008054562 sameAs 2008054562 @default.
• W2008054562 citedByCount "49" @default.
• W2008054562 countsByYear W20080545622012 @default.
• W2008054562 countsByYear W20080545622013 @default.
• W2008054562 countsByYear W20080545622014 @default.
• W2008054562 countsByYear W20080545622015 @default.
• W2008054562 countsByYear W20080545622016 @default.
• W2008054562 countsByYear W20080545622017 @default.
• W2008054562 countsByYear W20080545622018 @default.
• W2008054562 countsByYear W20080545622021 @default.
• W2008054562 crossrefType "journal-article" @default.
• W2008054562 hasAuthorship W2008054562A5011977039 @default.
• W2008054562 hasAuthorship W2008054562A5031719052 @default.
• W2008054562 hasAuthorship W2008054562A5064312456 @default.
• W2008054562 hasAuthorship W2008054562A5077673040 @default.
• W2008054562 hasConcept C104317684 @default.
• W2008054562 hasConcept C105580179 @default.
• W2008054562 hasConcept C119795356 @default.
• W2008054562 hasConcept C141071460 @default.
• W2008054562 hasConcept C150194340 @default.
• W2008054562 hasConcept C153911025 @default.
• W2008054562 hasConcept C159110652 @default.
• W2008054562 hasConcept C181199279 @default.
• W2008054562 hasConcept C2776543447 @default.
• W2008054562 hasConcept C2776909242 @default.
• W2008054562 hasConcept C2778128677 @default.
• W2008054562 hasConcept C3675279 @default.
• W2008054562 hasConcept C38441620 @default.
• W2008054562 hasConcept C512185932 @default.
• W2008054562 hasConcept C55493867 @default.
• W2008054562 hasConcept C62826618 @default.
• W2008054562 hasConcept C67705224 @default.
• W2008054562 hasConcept C71924100 @default.
• W2008054562 hasConcept C86803240 @default.
• W2008054562 hasConceptScore W2008054562C104317684 @default.
• W2008054562 hasConceptScore W2008054562C105580179 @default.
• W2008054562 hasConceptScore W2008054562C119795356 @default.
• W2008054562 hasConceptScore W2008054562C141071460 @default.
• W2008054562 hasConceptScore W2008054562C150194340 @default.
• W2008054562 hasConceptScore W2008054562C153911025 @default.
• W2008054562 hasConceptScore W2008054562C159110652 @default.
• W2008054562 hasConceptScore W2008054562C181199279 @default.
• W2008054562 hasConceptScore W2008054562C2776543447 @default.
• W2008054562 hasConceptScore W2008054562C2776909242 @default.
• W2008054562 hasConceptScore W2008054562C2778128677 @default.
• W2008054562 hasConceptScore W2008054562C3675279 @default.
• W2008054562 hasConceptScore W2008054562C38441620 @default.
• W2008054562 hasConceptScore W2008054562C512185932 @default.
• W2008054562 hasConceptScore W2008054562C55493867 @default.
• W2008054562 hasConceptScore W2008054562C62826618 @default.
• W2008054562 hasConceptScore W2008054562C67705224 @default.
• W2008054562 hasConceptScore W2008054562C71924100 @default.
• W2008054562 hasConceptScore W2008054562C86803240 @default.
• W2008054562 hasIssue "1" @default.
• W2008054562 hasLocation W20080545621 @default.

• next