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- W2008054976 abstract "At presynaptic active zones, neurotransmitter release is initiated by the opening of voltage-gated Ca2+ channels close to docked vesicles. The mechanisms that enrich Ca2+ channels at active zones are, however, largely unknown, possibly because of the limited presynaptic accessibility of most synapses. Here, we have established a Cre-lox based conditional knockout approach at a presynaptically accessible central nervous system synapse, the calyx of Held, to directly study the functions of RIM proteins. Removal of all RIM1/2 isoforms strongly reduced the presynaptic Ca2+ channel density, revealing a role of RIM proteins in Ca2+ channel targeting. Removal of RIMs also reduced the readily releasable pool, paralleled by a similar reduction of the number of docked vesicles, and the Ca2+ channel-vesicle coupling was decreased. Thus, RIM proteins co-ordinately regulate key functions for fast transmitter release, enabling a high presynaptic Ca2+ channel density and vesicle docking at the active zone." @default.
- W2008054976 created "2016-06-24" @default.
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- W2008054976 date "2009-01-01" @default.
- W2008054976 modified "2023-09-24" @default.
- W2008054976 title "Synaptic and non-synaptic roles of neural activity in sensory map development." @default.
- W2008054976 doi "https://doi.org/10.1016/j.neures.2009.09.1510" @default.
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