Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008059275> ?p ?o ?g. }
- W2008059275 endingPage "70" @default.
- W2008059275 startingPage "63" @default.
- W2008059275 abstract "Since the discovery of the importance of nitric oxide (NO) to the human body three decades ago, numerous laboratory and clinical studies have been done to explore its potential therapeutic actions on many organs. In the cardiovascular system, NO works as a volatile signaling molecule regulating the vascular permeability and vascular tone, preventing thrombosis and inflammation, as well as inhibiting the smooth muscle hyperplasia. Thus, NO is important in the prevention and treatment of cardiovascular disease. NO is synthesized by NO synthase (NOS) with tetrahydrobiopterin (BH4) as the crucial cofactor. Many studies have been done to form nitric oxide donors so as to deliver NO directly to the vessel walls. In addition, NO moieties have been incorporated into existing therapeutic agents to enhance the NO bioavailability, including statins. Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA), the rate-limiting enzyme of the mevalonate pathway. By inhibiting this pathway, statins lower blood cholesterol and exert their pleiotropic effects through activity in reaction cascades, such as Rho/ROCK and Rac 1/NADPH oxidase pathways. Statins have also been observed to implement their non-lipid effects by promoting BH4 synthesis with increase of NO bioavailability. Furthermore, NO-donating statins in laboratory studies have demonstrated to produce better therapeutic effects than their parent's drugs. They offer better anti-inflammatory, anti-proliferative and antithrombotic actions on cardiovascular system. They also cause better revascularization in peripheral ischemia and produce greater enhancement in limb reperfusion and salvage. In addition, it has been shown that NO-donating statin caused less myotoxicity, the most common side effect related to treatment with statins. The initial studies have demonstrated the superior therapeutic effects of NO-donating statins while producing fewer side effects." @default.
- W2008059275 created "2016-06-24" @default.
- W2008059275 creator A5032145085 @default.
- W2008059275 creator A5084554219 @default.
- W2008059275 date "2014-11-01" @default.
- W2008059275 modified "2023-09-23" @default.
- W2008059275 title "Recent developments in the effects of nitric oxide-donating statins on cardiovascular disease through regulation of tetrahydrobiopterin and nitric oxide" @default.
- W2008059275 cites W1479760463 @default.
- W2008059275 cites W1563972510 @default.
- W2008059275 cites W1607892649 @default.
- W2008059275 cites W1675755394 @default.
- W2008059275 cites W1965982596 @default.
- W2008059275 cites W1977423544 @default.
- W2008059275 cites W1978859651 @default.
- W2008059275 cites W1978869728 @default.
- W2008059275 cites W1980406827 @default.
- W2008059275 cites W1985771948 @default.
- W2008059275 cites W1987686985 @default.
- W2008059275 cites W1990255353 @default.
- W2008059275 cites W1991846366 @default.
- W2008059275 cites W1991920032 @default.
- W2008059275 cites W1994135664 @default.
- W2008059275 cites W1997023449 @default.
- W2008059275 cites W1998424496 @default.
- W2008059275 cites W1998719302 @default.
- W2008059275 cites W2001992018 @default.
- W2008059275 cites W2004398529 @default.
- W2008059275 cites W2005281763 @default.
- W2008059275 cites W2007563528 @default.
- W2008059275 cites W2011089437 @default.
- W2008059275 cites W2018183499 @default.
- W2008059275 cites W2020706170 @default.
- W2008059275 cites W2021959636 @default.
- W2008059275 cites W2024660473 @default.
- W2008059275 cites W2024848503 @default.
- W2008059275 cites W2027218942 @default.
- W2008059275 cites W2027873788 @default.
- W2008059275 cites W2036463932 @default.
- W2008059275 cites W2037873251 @default.
- W2008059275 cites W2040982838 @default.
- W2008059275 cites W2045074426 @default.
- W2008059275 cites W2051380872 @default.
- W2008059275 cites W2058599067 @default.
- W2008059275 cites W2058890881 @default.
- W2008059275 cites W2064011020 @default.
- W2008059275 cites W2064709994 @default.
- W2008059275 cites W2068216054 @default.
- W2008059275 cites W2071186420 @default.
- W2008059275 cites W2074035327 @default.
- W2008059275 cites W2075812158 @default.
- W2008059275 cites W2077790464 @default.
- W2008059275 cites W2078047202 @default.
- W2008059275 cites W2082009220 @default.
- W2008059275 cites W2087685842 @default.
- W2008059275 cites W2089561842 @default.
- W2008059275 cites W2090840920 @default.
- W2008059275 cites W2091913907 @default.
- W2008059275 cites W2092042066 @default.
- W2008059275 cites W2094184870 @default.
- W2008059275 cites W2094746732 @default.
- W2008059275 cites W2101835986 @default.
- W2008059275 cites W2103500192 @default.
- W2008059275 cites W2104490980 @default.
- W2008059275 cites W2106121696 @default.
- W2008059275 cites W2106894101 @default.
- W2008059275 cites W2109353491 @default.
- W2008059275 cites W2114719488 @default.
- W2008059275 cites W2121174059 @default.
- W2008059275 cites W2122386753 @default.
- W2008059275 cites W2131750066 @default.
- W2008059275 cites W2138266022 @default.
- W2008059275 cites W2140890175 @default.
- W2008059275 cites W2148862064 @default.
- W2008059275 cites W2149896598 @default.
- W2008059275 cites W2153479034 @default.
- W2008059275 cites W2160897741 @default.
- W2008059275 cites W2164002943 @default.
- W2008059275 cites W2164765386 @default.
- W2008059275 cites W2170665083 @default.
- W2008059275 cites W2172004618 @default.
- W2008059275 cites W2323242909 @default.
- W2008059275 cites W2331449048 @default.
- W2008059275 cites W2341032132 @default.
- W2008059275 cites W2951998824 @default.
- W2008059275 cites W4241511363 @default.
- W2008059275 cites W4361868990 @default.
- W2008059275 cites W1931207646 @default.
- W2008059275 doi "https://doi.org/10.1016/j.vph.2014.08.001" @default.
- W2008059275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25139660" @default.
- W2008059275 hasPublicationYear "2014" @default.
- W2008059275 type Work @default.
- W2008059275 sameAs 2008059275 @default.
- W2008059275 citedByCount "16" @default.
- W2008059275 countsByYear W20080592752015 @default.
- W2008059275 countsByYear W20080592752016 @default.
- W2008059275 countsByYear W20080592752017 @default.
- W2008059275 countsByYear W20080592752018 @default.
- W2008059275 countsByYear W20080592752019 @default.