FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008062030> ?p ?o ?g. }

• W2008062030 endingPage "E261" @default.
• W2008062030 startingPage "E245" @default.
• W2008062030 abstract "Immobilization causes skeletal muscle atrophy via complex signaling pathways that are not well understood. To better understand these pathways, we investigated the roles of p53 and ATF4, two transcription factors that mediate adaptations to a variety of cellular stresses. Using mouse models, we demonstrate that 3 days of muscle immobilization induces muscle atrophy and increases expression of p53 and ATF4. Furthermore, muscle fibers lacking p53 or ATF4 are partially resistant to immobilization-induced muscle atrophy, and forced expression of p53 or ATF4 induces muscle fiber atrophy in the absence of immobilization. Importantly, however, p53 and ATF4 do not require each other to promote atrophy, and coexpression of p53 and ATF4 induces more atrophy than either transcription factor alone. Moreover, muscle fibers lacking both p53 and ATF4 are more resistant to immobilization-induced atrophy than fibers lacking only p53 or ATF4. Interestingly, the independent and additive nature of the p53 and ATF4 pathways allows for combinatorial control of at least one downstream effector, p21. Using genome-wide mRNA expression arrays, we identified p21 mRNA as a skeletal muscle transcript that is highly induced in immobilized muscle via the combined actions of p53 and ATF4. Additionally, in mouse muscle, p21 induces atrophy in a manner that does not require immobilization, p53 or ATF4, and p21 is required for atrophy induced by immobilization, p53, and ATF4. Collectively, these results identify p53 and ATF4 as essential and complementary mediators of immobilization-induced muscle atrophy and discover p21 as a critical downstream effector of the p53 and ATF4 pathways." @default.
• W2008062030 created "2016-06-24" @default.
• W2008062030 creator A5013787976 @default.
• W2008062030 creator A5016363572 @default.
• W2008062030 creator A5045934190 @default.
• W2008062030 creator A5049877571 @default.
• W2008062030 creator A5052957054 @default.
• W2008062030 creator A5061599421 @default.
• W2008062030 creator A5065825551 @default.
• W2008062030 creator A5086761740 @default.
• W2008062030 date "2014-08-01" @default.
• W2008062030 modified "2023-10-17" @default.
• W2008062030 title "p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization" @default.
• W2008062030 cites W1484492220 @default.
• W2008062030 cites W1494864623 @default.
• W2008062030 cites W1575363584 @default.
• W2008062030 cites W1965629756 @default.
• W2008062030 cites W1966636083 @default.
• W2008062030 cites W1967338134 @default.
• W2008062030 cites W1967387547 @default.
• W2008062030 cites W1968220278 @default.
• W2008062030 cites W1970462947 @default.
• W2008062030 cites W1972618720 @default.
• W2008062030 cites W1973480874 @default.
• W2008062030 cites W1978345311 @default.
• W2008062030 cites W1978518304 @default.
• W2008062030 cites W1986179131 @default.
• W2008062030 cites W1994917595 @default.
• W2008062030 cites W2005989770 @default.
• W2008062030 cites W2014899456 @default.
• W2008062030 cites W2015519364 @default.
• W2008062030 cites W2023470228 @default.
• W2008062030 cites W2025722611 @default.
• W2008062030 cites W2026932801 @default.
• W2008062030 cites W2028446721 @default.
• W2008062030 cites W2035188342 @default.
• W2008062030 cites W2035205542 @default.
• W2008062030 cites W2035555824 @default.
• W2008062030 cites W2038173255 @default.
• W2008062030 cites W2044057392 @default.
• W2008062030 cites W2045438156 @default.
• W2008062030 cites W2051233997 @default.
• W2008062030 cites W2053127486 @default.
• W2008062030 cites W2056723619 @default.
• W2008062030 cites W2058707564 @default.
• W2008062030 cites W2059083151 @default.
• W2008062030 cites W2073315283 @default.
• W2008062030 cites W2077573372 @default.
• W2008062030 cites W2083991264 @default.
• W2008062030 cites W2086589468 @default.
• W2008062030 cites W2087408740 @default.
• W2008062030 cites W2096536853 @default.
• W2008062030 cites W2097103188 @default.
• W2008062030 cites W2097489686 @default.
• W2008062030 cites W2098415496 @default.
• W2008062030 cites W2099582158 @default.
• W2008062030 cites W2107979620 @default.
• W2008062030 cites W2113701180 @default.
• W2008062030 cites W2116520593 @default.
• W2008062030 cites W2124959176 @default.
• W2008062030 cites W2128693866 @default.
• W2008062030 cites W2131632095 @default.
• W2008062030 cites W2141573001 @default.
• W2008062030 cites W2141645735 @default.
• W2008062030 cites W2147294934 @default.
• W2008062030 cites W2148958834 @default.
• W2008062030 cites W2149013144 @default.
• W2008062030 cites W2151199834 @default.
• W2008062030 cites W2151988383 @default.
• W2008062030 cites W2152073834 @default.
• W2008062030 cites W2162262059 @default.
• W2008062030 cites W2165209275 @default.
• W2008062030 cites W2166633890 @default.
• W2008062030 cites W2167033587 @default.
• W2008062030 cites W4236839954 @default.
• W2008062030 cites W4250973782 @default.
• W2008062030 doi "https://doi.org/10.1152/ajpendo.00010.2014" @default.
• W2008062030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4121573" @default.
• W2008062030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24895282" @default.
• W2008062030 hasPublicationYear "2014" @default.
• W2008062030 type Work @default.
• W2008062030 sameAs 2008062030 @default.
• W2008062030 citedByCount "86" @default.
• W2008062030 countsByYear W20080620302014 @default.
• W2008062030 countsByYear W20080620302015 @default.
• W2008062030 countsByYear W20080620302016 @default.
• W2008062030 countsByYear W20080620302017 @default.
• W2008062030 countsByYear W20080620302018 @default.
• W2008062030 countsByYear W20080620302019 @default.
• W2008062030 countsByYear W20080620302020 @default.
• W2008062030 countsByYear W20080620302021 @default.
• W2008062030 countsByYear W20080620302022 @default.
• W2008062030 countsByYear W20080620302023 @default.
• W2008062030 crossrefType "journal-article" @default.
• W2008062030 hasAuthorship W2008062030A5013787976 @default.
• W2008062030 hasAuthorship W2008062030A5016363572 @default.
• W2008062030 hasAuthorship W2008062030A5045934190 @default.
• W2008062030 hasAuthorship W2008062030A5049877571 @default.

• next