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• W2008062202 abstract "Over the last two decades, electrophilic catalysis relying on platinum(II), gold(I), and gold(III) salts has emerged as a remarkable synthetic methodology. Chemists have discovered a large variety of organic transformations that convert a great assortment of highly functionalized precursors into valuable final products. In many cases, these methodologies offer unique features, allowing access to unprecedented molecular architectures. Due to the mild reaction conditions and high function compatibility, scientists have successfully developed applications in total synthesis of natural products, as well as in asymmetric catalysis. In addition, all these developments have been accompanied by the invention of well-tailored catalysts, so that a palette of different electrophilic agents is now commercially available or readily synthesized at the bench.In some respects, researchers’ interests in developing homogeneous gold catalysis can be compared with the Californian gold rush of the 19th century. It has attracted into its fervor thousands of scientists, providing a huge number of versatile and important reports. More notably, it is clear that the contribution to the art of organic synthesis is very valuable, though the quest is not over yet. Because they rely on the intervention of previously unknown types of intermediates, new retrosynthetic disconnections are now possible.In this Account, we discuss our efforts on the use of readily available polyunsaturated precursors, such as enynes, dienynes, allenynes, and allenenes to give access to highly original polycyclic structures in a single operation. These transformations transit via previously undescribed intermediates A, B, D, F, and H that will be encountered later on. All these intermediates have been determined by both ourselves and others by DFT calculations and in some cases have been confirmed on the basis of experimental data. In addition, dual gold activation can be at work in some of these transformations, for instance, from E to F.Strikingly, we have found propargyl acetates to be particularly productive precursors. In a preliminary step upon electrophilic activation (complex I), they can lead to oxonium J or a vinylcarbenoid species K after 1,2-migration or complexed allenylester M from a formal 1,3-migration. All of them can serve as versatile entries for multievent processes. The propargyl cycle, sometimes called the golden carousel, involves species I–N), which lie in a close equilibrium. The control of this merry-go-round and its offshoots depends on the energy barriers associated with the subsequent reactions of these intermediates.We illustrate these themes in this Account, focusing on the intriguing characteristics of gold catalysis." @default.
• W2008062202 created "2016-06-24" @default.
• W2008062202 creator A5007317946 @default.
• W2008062202 creator A5084109287 @default.
• W2008062202 date "2014-02-24" @default.
• W2008062202 modified "2023-10-04" @default.
• W2008062202 title "Molecular Complexity from Polyunsaturated Substrates: The Gold Catalysis Approach" @default.
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