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- W2008064947 abstract "The direct renal effects of glucagon were studied in 13 dogs. Glucagon was infused in dilute solution directly into one renal artery for 4 clearance periods of 20 minutes each, and the differences between kidneys in GFR, ERPF, FF, and excretory rates of Na, Cl, K, H2O, P, Ca, and Mg were compared with differences observed during the immediately preceding four 20-minute periods during which 0.85 per cent saline was infused into one kidney. The differences between kidneys during saline infusion were small or insignificant. Glucagon infusion produced a bilateral rise in GFR and FF, of about the same degree in each kidney. In all except the intial glucagon period, however, there was no difference in GFR, ERPF, or FF between the infused kidney and its mate. There was a small, statistically significant rise in differential GFR for the first glucagon period but not for the remaining 3 periods. Glucagon produced a marked differential increase in excretion of all measured ions; the sodium increase was the largest. The results support the conclusion that glucagon acts directly upon the renal tubule to decrease the reabsorption of Na, Cl, H2O, Ca, and Mg, and to decrease the “net” tubular reabsorption of K." @default.
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- W2008064947 title "Direct effects of glucagon on renal hemodynamics and excretion of inorganic ions" @default.
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- W2008064947 doi "https://doi.org/10.1016/0026-0495(67)90047-9" @default.
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