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- W2008068073 abstract "Important goals of current immunological research are to gain an understanding as to how antigens are processed and how they bind to T-cell receptors to generate the appropriate signals that lead to cell activation and gene expression. Work in our laboratories has identified a T-cell mitogen (MAM) which is produced by Mycoplasma arthritidis, a potent arthritogenic agent of mice and rats (10). This mitogen has several unique features that may help us to understand how antigens activate T cells and may also suggest the existence of a new pathway of T-cell activation. MAM can be recovered from culture supernatants of M. arthritidis. It is a heat labile, cationic protein with a pI of >9.0 and an of 15,000 (1, 13). MAM can exist in larger Mr forms due to its ability to associate with other molecules present in culture media (1). MAM is remarkably potent, giving 50% of maximum stimulation of mouse lymphocytes at <10-11M." @default.
- W2008068073 created "2016-06-24" @default.
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- W2008068073 date "1988-07-01" @default.
- W2008068073 modified "2023-09-25" @default.
- W2008068073 title "Mycoplasma arthritidis mitogen: A potential new pathway of T-cell activation" @default.
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- W2008068073 doi "https://doi.org/10.1016/0197-1859(88)90041-6" @default.
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