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- W2008071566 abstract "The elimination half-life (t½E) of lithium carbonate in red blood cells, plasma, and urine was measured in 30 patients hospitalized for primary affective disorder. Duration of Li treatment at time of sampling was found to have a direct effect on lengthening time course. Patients on their initial course of Li had the lowest t½s: 1.12 (urine), 1.28 (plasma), and 1.22 days (red blood cells); those less than 1 yr on Li had intermediate values: 1.85, 1.65, and 1.75 days; and those more than 1 continous year on Li had the longest mean t½s: 2.40, 2.43, and 2.24 days. These results for urine (p < 0.01) and plasma (p < 0.05) are further evidence that Li may stimulate the production of an endogenous regulator of Li efflux. This regulator may prove to be an important factor in planning of long-term Li prophylaxis. Clinical Pharmacology and Therapeutics (1981) 29, 47–50; doi:10.1038/clpt.1981.8" @default.
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- W2008071566 date "1981-01-01" @default.
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- W2008071566 title "Lithium elimination half-life and duration of therapy" @default.
- W2008071566 doi "https://doi.org/10.1038/clpt.1981.8" @default.
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