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• W2008077816 abstract "The reverse transcriptase (RT) of HIV-1 has a non-templated addition (NTA) activity and can perform template switches with a very short (even two nucleotides) complementarity between the 3′-ends of the primer donor strand and the template acceptor strands [1]. We have studied how the combination of several pivotal parameters can all lead to strand switches during DNA synthesis by HIV-1 RT. These include dNTP bias in the NTA step, the availability of acceptor strands with 3′-end sequences complementary to the de novo-generated primer tails and the stabilities of the clamped duplexes formed between these primer tails and the acceptor strands." @default.
• W2008077816 created "2016-06-24" @default.
• W2008077816 creator A5049821570 @default.
• W2008077816 creator A5075846591 @default.
• W2008077816 date "2011-05-01" @default.
• W2008077816 modified "2023-09-25" @default.
• W2008077816 title "Strand selections resulting from the combined template-independent DNA synthesis and clamp activities of HIV-1 reverse transcriptase" @default.
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• W2008077816 doi "https://doi.org/10.1016/j.bbrc.2011.04.063" @default.
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