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• W2008081430 abstract "Granulosa cell tumours of the ovary (GCT) exhibit high expression of estrogen receptor β (ERβ). A role for estrogen receptors in these tumours may depend on altered co-activator expression. This study examines the expression of the co-activators SRC-1a/e, SRC-2, SRC-3, SRA, and the corepressors NCoR and SMRT in GCT, epithelial ovarian tumours and normal ovary. No significant difference in the expression of SRC-1, SRC-2, SRC-3 or NCoR and SMRT was found. In particular, there was no correlation of co-activator expression with ERβ expression. There was a significant upregulation in the expression of the novel RNA co-activator SRA in the serous tumours compared with the other tumour types and normal ovary. The findings suggest that ERβ may require co-activators, other than members of the SRC family for the modulation of transcription in GCT." @default.
• W2008081430 created "2016-06-24" @default.
• W2008081430 creator A5046419066 @default.
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• W2008081430 date "2005-01-01" @default.
• W2008081430 modified "2023-10-10" @default.
• W2008081430 title "Expression of nuclear receptor coregulators in ovarian stromal and epithelial tumours" @default.
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• W2008081430 doi "https://doi.org/10.1016/j.mce.2004.08.005" @default.
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