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• W2008082482 abstract "Glucose has been thought to be the primary substrate for energy metabolism in the developing lung; however, alternate substrates are used for energy metabolism in other organs. To examine the role of alternate substrates in the lung, we measured rates of oxidation of glutamine, glucose, lactate, and 3-hydroxybutyrate in type II pneumocytes isolated from d 19 fetal rat lungs by measuring the production of 14CO2 from labeled substrates. Glutamine had a rate of 24.36 ± 4.51 nmol 14CO2 produced/h/mg of protein (mean ± SEM), whereas lactate had a significantly higher rate, 40.29 ± 4.42. 3-Hydroxybutyrate had a rate of 14.91 ± 1.93. The rate of glucose oxidation was 2.13 ± 0.36, significantly lower than that of glutamine. To examine the interactions of substrates normally found in the intracellular milieu, we measured the effect of unlabeled substrates as competitors on labeled substrate. This identifies multiple metabolic compartments of energy metabolism. Glucose, but not lactate, inhibited the oxidation of glutamine, suggesting a compartmentation of tricarboxylic acid cycle activity, rather than simple dilution by glucose. Glucose and lactate had reciprocal inhibition. Our data suggest at least two separate compartments in the type II cells for substrate oxidation, one for glutamine metabolism and a second for glucose metabolism. In summary, we have documented that glutamine and other alternate substrates are oxidized preferentially over glucose for energy metabolism in the d 19 fetal rat lung type II pneumocyte. In addition, we have delineated some of the compartmentation that occurs within the developing type II cell, which may determine how these substrates are used." @default.
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• W2008082482 date "1996-07-01" @default.
• W2008082482 modified "2023-10-14" @default.
• W2008082482 title "The Role of Glutamine and Other Alternate Substrates as Energy Sources in the Fetal Rat Lung Type II Cell1" @default.
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• W2008082482 doi "https://doi.org/10.1203/00006450-199607000-00023" @default.
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