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- W2008085654 abstract "We have previously reported identification of a phosphorothioate oligonucleotide TTGGGGTT (ISIS 5320) as a potent inhibitor of HIV infection in vitro. The oligonucleotide forms a parallel-stranded, tetrameric guanosine quartet (G-quartet) structure that specifically binds to the HIV envelope glycoprotein (gp120) and inhibits both cell-to-cell and virus-to-cell infection at submicromolar concentrations. In the current study we demonstrate that the tetramer inhibits the infection of laboratory-derived isolates of HIV-1 and HIV-2 in a variety of phenotypically distinct, established human cell lines and a panel of biologically diverse clinical isolates in fresh human peripheral blood lymphocytes and macrophages. The compound was also active against all drug-resistant virus isolates tested. In combination with AZT, ISIS 5320 exhibits additive to slightly synergistic anti-HIV activity. Cell-based mechanism of action studies demonstrate that the compound inhibits the binding of infectious virus and virus-infected cells to uninfected target cells by binding to the cationic V3 loop of the envelope glycoprotein. The G-quartet structure is a potential candidate for use in anti-HIV chemotherapy." @default.
- W2008085654 created "2016-06-24" @default.
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- W2008085654 date "1994-11-01" @default.
- W2008085654 modified "2023-09-26" @default.
- W2008085654 title "Potent and Specific Inhibition of HIV Envelope-Mediated Cell Fusion and Virus Binding by G Quartet-Forming Oligonucleotide (ISIS 5320)" @default.
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- W2008085654 doi "https://doi.org/10.1089/aid.1994.10.1497" @default.
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