FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008088358> ?p ?o ?g. }

• W2008088358 endingPage "2134" @default.
• W2008088358 startingPage "2134" @default.
• W2008088358 abstract "purpose. Macular pigment (MP) is composed of two dietary carotenoids, lutein and zeaxanthin, and a carotenoid generated by the retina, meso-zeaxanthin. There is large intersubject variability in peak optical density, spatial profile, and lateral extent of macular pigment, and it has been suggested that foveal architecture may play a role in this variability. This study is an initial investigation of the relationship between the spatial profile of macular pigment and foveal architecture. methods. Sixty normal subjects were enrolled (one was eventually excluded). The spatial profile of macular pigment optical density (MPOD) was measured by customized heterochromatic flicker photometry (cHFP). High-resolution macular thickness maps were obtained by optical coherence tomography. Four parameters were analyzed: (1) minimum foveal thickness (MFT) at the intersection of six radial scans; (2) central foveal thickness (CFT) averaged over the central 1 mm of the fovea; (3) foveal width identified as the region lacking a nerve fiber layer; and (4) foveal width measured from crest to crest. Lifestyle and vision information were obtained by questionnaire. results. The mean ± SD MPOD at 0.25° eccentricity was 0.49 ± 0.23 and at 0.5° eccentricity, 0.41 ± 0.21. A first-order decreasing exponential function accounted for most of the variance of the MP profile averaged across subjects (r 2 = 0.99). MPOD measured at 0.25° was unrelated to both measures of foveal thickness for the entire study group (r = 0.03, P = 0.81, and r = −0.08, P = 0.57, respectively). Similarly, MPOD measured at 0.5° was unrelated to foveal thickness in the entire study group (r = 0.12, P = 0.36 and r = −0.05, P = 0.71, respectively). However, when analyzed separately in the nonwhite subjects, the relationship between MPOD at 0.25° and MFT was positive and significant (r = 0.59, P = 0.01), but remained unrelated to CFT (r = 0.20, P = 0.41). Similarly, in the nonwhite subjects, the relationship between MPOD at 0.5° and MFT was positive and significant (r = 0.68, P < 0.01), but again was unrelated to CFT (r = 0.23, P = 0.32). There was no significant relationship between MPOD and either measure of foveal thickness in the white subjects. In the entire study group, there was a positive and significant relationship between foveal width and MPOD averaged across the fovea (r = 0.41, P < 0.01) and between foveal width and MP integrated across the fovea (r = 0.41, P < 0.01). conclusions. Foveal MP was positively and significantly related to foveal width in the entire study group. This relationship may be determined by the greater length of the cone axons (Henle fibers) in wider foveas. MPOD was unrelated to foveal thickness in the white subjects. However, in the nonwhite subjects there was a positive association between MFT and MPOD at the 0.25° and 0.5° eccentricities, suggesting that other personal characteristics modulate the MPOD–retinal thickness relationship." @default.
• W2008088358 created "2016-06-24" @default.
• W2008088358 creator A5050985954 @default.
• W2008088358 creator A5053495034 @default.
• W2008088358 creator A5062169058 @default.
• W2008088358 creator A5084759633 @default.
• W2008088358 date "2008-05-01" @default.
• W2008088358 modified "2023-10-06" @default.
• W2008088358 title "Spatial Profile of Macular Pigment and Its Relationship to Foveal Architecture" @default.
• W2008088358 cites W126033127 @default.
• W2008088358 cites W1479899811 @default.
• W2008088358 cites W1490322554 @default.
• W2008088358 cites W1503604250 @default.
• W2008088358 cites W151625338 @default.
• W2008088358 cites W1517648334 @default.
• W2008088358 cites W1559066926 @default.
• W2008088358 cites W1585553871 @default.
• W2008088358 cites W1976935136 @default.
• W2008088358 cites W1977286054 @default.
• W2008088358 cites W1977720404 @default.
• W2008088358 cites W1985283672 @default.
• W2008088358 cites W1994168026 @default.
• W2008088358 cites W2000061236 @default.
• W2008088358 cites W2005657736 @default.
• W2008088358 cites W2005751391 @default.
• W2008088358 cites W2010453646 @default.
• W2008088358 cites W2023628478 @default.
• W2008088358 cites W2044201543 @default.
• W2008088358 cites W2048593585 @default.
• W2008088358 cites W2056575109 @default.
• W2008088358 cites W2062991617 @default.
• W2008088358 cites W2066097607 @default.
• W2008088358 cites W2074193367 @default.
• W2008088358 cites W2078828432 @default.
• W2008088358 cites W2091902598 @default.
• W2008088358 cites W2112126613 @default.
• W2008088358 cites W2128304593 @default.
• W2008088358 cites W2152442518 @default.
• W2008088358 cites W2155535481 @default.
• W2008088358 cites W2171463916 @default.
• W2008088358 cites W62599577 @default.
• W2008088358 doi "https://doi.org/10.1167/iovs.07-0933" @default.
• W2008088358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18436846" @default.
• W2008088358 hasPublicationYear "2008" @default.
• W2008088358 type Work @default.
• W2008088358 sameAs 2008088358 @default.
• W2008088358 citedByCount "87" @default.
• W2008088358 countsByYear W20080883582012 @default.
• W2008088358 countsByYear W20080883582013 @default.
• W2008088358 countsByYear W20080883582014 @default.
• W2008088358 countsByYear W20080883582015 @default.
• W2008088358 countsByYear W20080883582016 @default.
• W2008088358 countsByYear W20080883582017 @default.
• W2008088358 countsByYear W20080883582018 @default.
• W2008088358 countsByYear W20080883582019 @default.
• W2008088358 countsByYear W20080883582020 @default.
• W2008088358 countsByYear W20080883582021 @default.
• W2008088358 countsByYear W20080883582022 @default.
• W2008088358 countsByYear W20080883582023 @default.
• W2008088358 crossrefType "journal-article" @default.
• W2008088358 hasAuthorship W2008088358A5050985954 @default.
• W2008088358 hasAuthorship W2008088358A5053495034 @default.
• W2008088358 hasAuthorship W2008088358A5062169058 @default.
• W2008088358 hasAuthorship W2008088358A5084759633 @default.
• W2008088358 hasBestOaLocation W20080883581 @default.
• W2008088358 hasConcept C118487528 @default.
• W2008088358 hasConcept C119767625 @default.
• W2008088358 hasConcept C120665830 @default.
• W2008088358 hasConcept C121332964 @default.
• W2008088358 hasConcept C150846664 @default.
• W2008088358 hasConcept C185592680 @default.
• W2008088358 hasConcept C192562407 @default.
• W2008088358 hasConcept C2776099141 @default.
• W2008088358 hasConcept C2778411929 @default.
• W2008088358 hasConcept C2778818243 @default.
• W2008088358 hasConcept C2779736970 @default.
• W2008088358 hasConcept C2780827179 @default.
• W2008088358 hasConcept C28781525 @default.
• W2008088358 hasConcept C30181142 @default.
• W2008088358 hasConcept C31903555 @default.
• W2008088358 hasConcept C44870925 @default.
• W2008088358 hasConcept C68271606 @default.
• W2008088358 hasConcept C71924100 @default.
• W2008088358 hasConceptScore W2008088358C118487528 @default.
• W2008088358 hasConceptScore W2008088358C119767625 @default.
• W2008088358 hasConceptScore W2008088358C120665830 @default.
• W2008088358 hasConceptScore W2008088358C121332964 @default.
• W2008088358 hasConceptScore W2008088358C150846664 @default.
• W2008088358 hasConceptScore W2008088358C185592680 @default.
• W2008088358 hasConceptScore W2008088358C192562407 @default.
• W2008088358 hasConceptScore W2008088358C2776099141 @default.
• W2008088358 hasConceptScore W2008088358C2778411929 @default.
• W2008088358 hasConceptScore W2008088358C2778818243 @default.
• W2008088358 hasConceptScore W2008088358C2779736970 @default.
• W2008088358 hasConceptScore W2008088358C2780827179 @default.
• W2008088358 hasConceptScore W2008088358C28781525 @default.
• W2008088358 hasConceptScore W2008088358C30181142 @default.
• W2008088358 hasConceptScore W2008088358C31903555 @default.

• next