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- W2008092922 abstract "The neuroregenerative properties of FK506, an FKBP-12 ligand that inhibits calcineurin, and V-10,367, an FKBP-12 ligand that does not inhibit calcineurin, were evaluated in crush and transection models. Rats were randomly assigned to one of seven groups, including untreated controls and FK506- or V-10,367-treated experimental groups. Following crush or transection nerve injury, animals were assessed with walking tracks, and histomorphometry. FK506-treated animals demonstrated significant functional recovery 11 days following crush and 18 days following transection injury. In untreated and V-10,367 treated animals, nerves recovered 13 days following crush injury, but did not improve significantly prior to sacrifice at 28 days in animals sustaining a transection injury. No statistically significant differences in histomorphometric parameters were identified between any of the groups. The study confirms that FK506 accelerates recovery from tibial nerve injury." @default.
- W2008092922 created "2016-06-24" @default.
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- W2008092922 date "2000-01-01" @default.
- W2008092922 modified "2023-10-10" @default.
- W2008092922 title "Effects of Fkbp-12 Ligands Following Tibial Nerve Injury in Rats" @default.
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- W2008092922 doi "https://doi.org/10.1055/s-2000-9379" @default.
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