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- W2008092954 abstract "Current research in molecular genetics and molecular cell biology has disclosed that Alzheimer's disease (AD) is composed of a number of etiologically heterogenous disorders. In dominantly inherited early onset AD, the missense mutations found in the genes encoding amyloid precursor protein (APP), presenilin-1, and/or presenilin-2, are all known to increase the production and secretion of Aβ1–42(43). The abnormal deposition of Aβ1–42 is currently considered to play a key role in triggering a pathological array of symptoms in AD. Investigation of the molecular mechanism causing dominant AD provides a powerful model to understand the etiology of sporadic late-onset AD, whose mechanism remains unknown." @default.
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- W2008092954 date "1998-03-01" @default.
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- W2008092954 title "The implications of genetic studies on the pathogenesis of Alzheimer's disease" @default.
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- W2008092954 doi "https://doi.org/10.1111/j.1440-1789.1998.tb00086.x" @default.
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