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• W2008093120 abstract "Protein S-acylation, the reversible covalent fatty-acid modification of cysteine residues, has emerged as a dynamic posttranslational modification (PTM) that controls the diversity, life cycle, and physiological function of numerous ligand- and voltage-gated ion channels. S-acylation is enzymatically mediated by a diverse family of acyltransferases (zDHHCs) and is reversed by acylthioesterases. However, for most ion channels, the dynamics and subcellular localization at which S-acylation and deacylation cycles occur are not known. S-acylation can control the two fundamental determinants of ion channel function: (1) the number of channels resident in a membrane and (2) the activity of the channel at the membrane. It controls the former by regulating channel trafficking and the latter by controlling channel kinetics and modulation by other PTMs. Ion channel function may be modulated by S-acylation of both pore-forming and regulatory subunits as well as through control of adapter, signaling, and scaffolding proteins in ion channel complexes. Importantly, cross-talk of S-acylation with other PTMs of both cysteine residues by themselves and neighboring sites of phosphorylation is an emerging concept in the control of ion channel physiology. In this review, I discuss the fundamentals of protein S-acylation and the tools available to investigate ion channel S-acylation. The mechanisms and role of S-acylation in controlling diverse stages of the ion channel life cycle and its effect on ion channel function are highlighted. Finally, I discuss future goals and challenges for the field to understand both the mechanistic basis for S-acylation control of ion channels and the functional consequence and implications for understanding the physiological function of ion channel S-acylation in health and disease." @default.
• W2008093120 created "2016-06-24" @default.
• W2008093120 creator A5038432586 @default.
• W2008093120 date "2014-05-12" @default.
• W2008093120 modified "2023-10-02" @default.
• W2008093120 title "Ion channel regulation by protein S-acylation" @default.
• W2008093120 cites W1517742055 @default.
• W2008093120 cites W1539776973 @default.
• W2008093120 cites W1573864704 @default.
• W2008093120 cites W1592441314 @default.
• W2008093120 cites W1609531590 @default.
• W2008093120 cites W1964140147 @default.
• W2008093120 cites W1968212152 @default.
• W2008093120 cites W1969507814 @default.
• W2008093120 cites W1969943031 @default.
• W2008093120 cites W1970047246 @default.
• W2008093120 cites W1970637513 @default.
• W2008093120 cites W1971778800 @default.
• W2008093120 cites W1972681439 @default.
• W2008093120 cites W1972842487 @default.
• W2008093120 cites W1972907910 @default.
• W2008093120 cites W1973664032 @default.
• W2008093120 cites W1974374321 @default.
• W2008093120 cites W1975983905 @default.
• W2008093120 cites W1976573258 @default.
• W2008093120 cites W1980843814 @default.
• W2008093120 cites W1984533404 @default.
• W2008093120 cites W1984767023 @default.
• W2008093120 cites W1985184937 @default.
• W2008093120 cites W1986698046 @default.
• W2008093120 cites W1993556675 @default.
• W2008093120 cites W1996457989 @default.
• W2008093120 cites W1997219785 @default.
• W2008093120 cites W1997335993 @default.
• W2008093120 cites W1998917031 @default.
• W2008093120 cites W2001516087 @default.
• W2008093120 cites W2001679254 @default.
• W2008093120 cites W2002569944 @default.
• W2008093120 cites W2002573954 @default.
• W2008093120 cites W2004438254 @default.
• W2008093120 cites W2005925956 @default.
• W2008093120 cites W2006259718 @default.
• W2008093120 cites W2009010241 @default.
• W2008093120 cites W2009157389 @default.
• W2008093120 cites W2010554726 @default.
• W2008093120 cites W2011859788 @default.
• W2008093120 cites W2017196458 @default.
• W2008093120 cites W2018458016 @default.
• W2008093120 cites W2018508542 @default.
• W2008093120 cites W2020392031 @default.
• W2008093120 cites W2021057279 @default.
• W2008093120 cites W2022060021 @default.
• W2008093120 cites W2024715111 @default.
• W2008093120 cites W2028824717 @default.
• W2008093120 cites W2029359382 @default.
• W2008093120 cites W2030272696 @default.
• W2008093120 cites W2033852302 @default.
• W2008093120 cites W2034324831 @default.
• W2008093120 cites W2034502353 @default.
• W2008093120 cites W2034512365 @default.
• W2008093120 cites W2035834152 @default.
• W2008093120 cites W2036668494 @default.
• W2008093120 cites W2038133979 @default.
• W2008093120 cites W2039132353 @default.
• W2008093120 cites W2039446946 @default.
• W2008093120 cites W2046538616 @default.
• W2008093120 cites W2048247819 @default.
• W2008093120 cites W2048532536 @default.
• W2008093120 cites W2048559110 @default.
• W2008093120 cites W2050113155 @default.
• W2008093120 cites W2051506105 @default.
• W2008093120 cites W2051808752 @default.
• W2008093120 cites W2051816135 @default.
• W2008093120 cites W2055832264 @default.
• W2008093120 cites W2057853885 @default.
• W2008093120 cites W2058078854 @default.
• W2008093120 cites W2058369885 @default.
• W2008093120 cites W2059136279 @default.
• W2008093120 cites W2059407885 @default.
• W2008093120 cites W2060244476 @default.
• W2008093120 cites W2060904722 @default.
• W2008093120 cites W2062583344 @default.
• W2008093120 cites W2063115478 @default.
• W2008093120 cites W2064164064 @default.
• W2008093120 cites W2064990000 @default.
• W2008093120 cites W2064994601 @default.
• W2008093120 cites W2068034774 @default.
• W2008093120 cites W2068222855 @default.
• W2008093120 cites W2068612489 @default.
• W2008093120 cites W2068833431 @default.
• W2008093120 cites W2070562574 @default.
• W2008093120 cites W2070591591 @default.
• W2008093120 cites W2072565300 @default.
• W2008093120 cites W2072819360 @default.
• W2008093120 cites W2073864758 @default.
• W2008093120 cites W2075514757 @default.
• W2008093120 cites W2076996214 @default.
• W2008093120 cites W2077142293 @default.

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