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• W2008093250 abstract "Abstract Purpose To study the impact of Gd‐DTPA‐BMA on choline signals of HT29 colon carcinomas determined by localized 1 H MRS in vivo at 4.7T. Materials and Methods PRESS 1 H MR spectra (2‐second repetition time and echo times of 20–272 msec) were acquired from HT29 xenografts prior to and following intravenous administration of 0.1 or 0.2 mmol/kg Gd‐DTPA‐BMA. The magnetic resonance spectroscopy (MRS) data were analyzed by 1) normalizing choline and water peak areas to their precontrast values; and 2) estimating absolute choline concentration relative to tissue water. Results Changes in the T 1 and T 2 of choline and water were apparent following administration of Gd‐DTPA‐BMA. Administration of 0.1 mmol/kg Gd‐DTPA‐BMA induced significant increases in the choline peak area, concomitant with enhancements of the water peak area, whereas 0.2 mmol/kg Gd‐DTPA‐BMA induced no enhancement of choline peak area but significant increases in water peak area at short echo times. Conclusion The effect of Gd‐DTPA‐BMA on estimation of tumor choline concentration varied with the dose of contrast agent, the echo time, and the time after contrast agent administration. These data highlight the potential pitfalls associated with the modulation of choline and water signals post‐Gd‐DTPA‐BMA and may account for the apparently contradictory results previously reported. J. Magn. Reson. Imaging 2008;28:1201–1208. © 2008 Wiley‐Liss, Inc." @default.
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• W2008093250 date "2008-10-28" @default.
• W2008093250 modified "2023-10-18" @default.
• W2008093250 title "Effect of Gd-DTPA-BMA on choline signals of HT29 tumors detected by in vivo¹H MRS" @default.
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• W2008093250 doi "https://doi.org/10.1002/jmri.21577" @default.
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