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- W2008095148 abstract "The homeobox genegoosecoidmarks the Spemann organizer in vertebrate gastrula embryos, and is expressed in the craniofacial region, body wall and limbs during organogenesis. Mouse mutants ofgoosecoiddisplayed a variety of phenotypes related to the expression pattern at mid-embryogenesis. These defects included loss of the tympanic ring and malformation of the malleus, phenotypes which were reminiscent of the teratogenic effects of retinoic acid (RA). Here we investigated the correlation ofgoosecoidgene expression and RA-teratogenicity following treatment of mouse embryosin vivoat embryonic day (E) 8 + 5 h. We found thatgoosecoidwas specifically affected at E10.5 in branchial arches I and II. Expression was either reduced to background levels or restricted to the branchial cleft region. This change ingoosecoidgene expression correlated with a loss of middle ear ossicles and a partial or complete deletion of the tympanic ring, suggesting a role forgoosecoidin executing the RA teratogenic effects." @default.
- W2008095148 created "2016-06-24" @default.
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- W2008095148 date "1997-06-01" @default.
- W2008095148 modified "2023-10-18" @default.
- W2008095148 title "Correlation between Loss of Middle Ear Bones and AlteredgoosecoidGene Expression in the Branchial Region Following Retinoic Acid Treatment of Mouse Embryosin Vivo" @default.
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- W2008095148 doi "https://doi.org/10.1006/bbrc.1997.6808" @default.
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