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- W2008096229 abstract "Using the double whole-cell patch-clamp technique, we determined that dialysis of cell pairs by GTP[S] potentiated electrical uncoupling induced by extracellular addition of carbamylcholine (CCh). An inhibitor of diglyceride lipase, RHC 80267, further potentiated CCh/GTP[S]-induced junctional channel closure, probably by accumulation of diacylglycerol. Moreover, the protein kinase C inhibitor polymyxin B completely blocked uncoupling elicited by CCh/GTP[S]. These results provide the first evidence suggesting that gap junction channel closure by cholinergic stimulation is mediated by a G-protein, which acts by increasing phosphatidylinositol biphosphate breakdown and protein kinase C activity." @default.
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- W2008096229 date "1989-12-04" @default.
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- W2008096229 title "A G-protein mediates secretagogue-induced gap junctional channel closure in pancreatic acinar cells" @default.
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- W2008096229 doi "https://doi.org/10.1016/0014-5793(89)81656-4" @default.
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