Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008100118> ?p ?o ?g. }
- W2008100118 endingPage "4651" @default.
- W2008100118 startingPage "4640" @default.
- W2008100118 abstract "MicroRNAs (miRNAs) are central regulators of gene expression, and a large fraction of them are encoded in introns of RNA polymerase II transcripts. Thus, the biogenesis of intronic miRNAs by the microprocessor and the splicing of their host introns by the spliceosome require coordination between these processing events. This cross-talk is addressed here. We show that key microprocessor proteins Drosha and DGCR8 as well as pre-miRNAs cosediment with supraspliceosomes, where nuclear posttranscriptional processing is executed. We further show that inhibition of splicing increases miRNAs expression, whereas knock-down of Drosha increases splicing. We identified a novel splicing event in intron 13 of MCM7, where the miR-106b-25 cluster is located. The unique splice isoform includes a hosted pre-miRNA in the extended exon and excludes its processing. This indicates a possible mechanism of altering the levels of different miRNAs originating from the same transcript. Altogether, our study indicates interplay between the splicing and microprocessor machineries within a supraspliceosome context." @default.
- W2008100118 created "2016-06-24" @default.
- W2008100118 creator A5008264999 @default.
- W2008100118 creator A5045761416 @default.
- W2008100118 creator A5047459030 @default.
- W2008100118 creator A5083668720 @default.
- W2008100118 date "2014-01-23" @default.
- W2008100118 modified "2023-09-30" @default.
- W2008100118 title "Interplay between pre-mRNA splicing and microRNA biogenesis within the supraspliceosome" @default.
- W2008100118 cites W184528742 @default.
- W2008100118 cites W1964099801 @default.
- W2008100118 cites W1970302143 @default.
- W2008100118 cites W1972801928 @default.
- W2008100118 cites W1973975093 @default.
- W2008100118 cites W1978976893 @default.
- W2008100118 cites W1979782809 @default.
- W2008100118 cites W1980269624 @default.
- W2008100118 cites W1985880320 @default.
- W2008100118 cites W1997381798 @default.
- W2008100118 cites W2002364672 @default.
- W2008100118 cites W2004588189 @default.
- W2008100118 cites W2014064723 @default.
- W2008100118 cites W2020582053 @default.
- W2008100118 cites W2023438134 @default.
- W2008100118 cites W2031061513 @default.
- W2008100118 cites W2038182020 @default.
- W2008100118 cites W2042004955 @default.
- W2008100118 cites W2045402423 @default.
- W2008100118 cites W2045846885 @default.
- W2008100118 cites W2046379971 @default.
- W2008100118 cites W2048347652 @default.
- W2008100118 cites W2052065943 @default.
- W2008100118 cites W2052498125 @default.
- W2008100118 cites W2054109341 @default.
- W2008100118 cites W2057068701 @default.
- W2008100118 cites W2060678979 @default.
- W2008100118 cites W2061434726 @default.
- W2008100118 cites W2061664626 @default.
- W2008100118 cites W2063692299 @default.
- W2008100118 cites W2066213138 @default.
- W2008100118 cites W2071596792 @default.
- W2008100118 cites W2072155079 @default.
- W2008100118 cites W2073718731 @default.
- W2008100118 cites W2074616328 @default.
- W2008100118 cites W2082213106 @default.
- W2008100118 cites W2083260388 @default.
- W2008100118 cites W2093828809 @default.
- W2008100118 cites W2099517697 @default.
- W2008100118 cites W2099927467 @default.
- W2008100118 cites W2102261319 @default.
- W2008100118 cites W2103647350 @default.
- W2008100118 cites W2104521909 @default.
- W2008100118 cites W2105592180 @default.
- W2008100118 cites W2107277218 @default.
- W2008100118 cites W2113869362 @default.
- W2008100118 cites W2117991391 @default.
- W2008100118 cites W2124689160 @default.
- W2008100118 cites W2136148915 @default.
- W2008100118 cites W2136969669 @default.
- W2008100118 cites W2146970739 @default.
- W2008100118 cites W2151911276 @default.
- W2008100118 cites W2154841861 @default.
- W2008100118 cites W2155103924 @default.
- W2008100118 cites W2155742225 @default.
- W2008100118 cites W2157035190 @default.
- W2008100118 cites W2161149887 @default.
- W2008100118 cites W2161222316 @default.
- W2008100118 cites W2161859153 @default.
- W2008100118 cites W2162674813 @default.
- W2008100118 cites W2164496408 @default.
- W2008100118 cites W2165804743 @default.
- W2008100118 cites W2171230529 @default.
- W2008100118 doi "https://doi.org/10.1093/nar/gkt1413" @default.
- W2008100118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3985634" @default.
- W2008100118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24464992" @default.
- W2008100118 hasPublicationYear "2014" @default.
- W2008100118 type Work @default.
- W2008100118 sameAs 2008100118 @default.
- W2008100118 citedByCount "73" @default.
- W2008100118 countsByYear W20081001182014 @default.
- W2008100118 countsByYear W20081001182015 @default.
- W2008100118 countsByYear W20081001182016 @default.
- W2008100118 countsByYear W20081001182017 @default.
- W2008100118 countsByYear W20081001182018 @default.
- W2008100118 countsByYear W20081001182019 @default.
- W2008100118 countsByYear W20081001182020 @default.
- W2008100118 countsByYear W20081001182021 @default.
- W2008100118 countsByYear W20081001182022 @default.
- W2008100118 countsByYear W20081001182023 @default.
- W2008100118 crossrefType "journal-article" @default.
- W2008100118 hasAuthorship W2008100118A5008264999 @default.
- W2008100118 hasAuthorship W2008100118A5045761416 @default.
- W2008100118 hasAuthorship W2008100118A5047459030 @default.
- W2008100118 hasAuthorship W2008100118A5083668720 @default.
- W2008100118 hasBestOaLocation W20081001181 @default.
- W2008100118 hasConcept C104317684 @default.
- W2008100118 hasConcept C131934819 @default.
- W2008100118 hasConcept C145059251 @default.