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- W2008100329 abstract "Missense mutations within the central DNA binding region of p53 are the most prevalent mutations found in human cancer. Numerous studies indicate that 'hot-spot' p53 mutants (which comprise approximately 30% of human p53 gene mutations) are largely devoid of transcriptional activity. However, a growing body of evidence indicates that some non-hot-spot p53 mutants retain some degree of transcriptional activity in vivo, particularly against strong p53 binding sites. We have modified a previously described yeast-based p53 functional assay to readily identify such partial loss of function p53 mutants. We demonstrate the utility of this modified p53 functional assay using a diverse panel of p53 mutants." @default.
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- W2008100329 date "2001-03-01" @default.
- W2008100329 modified "2023-09-24" @default.
- W2008100329 title "Identification of partial loss of function p53 gene mutations utilizing a yeast-based functional assay" @default.
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- W2008100329 doi "https://doi.org/10.1093/nar/29.5.e28" @default.
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